| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 |
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| Ligand | BDBM243269 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
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| IC50 | <50±n/a nM |
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| Citation |  Poss, MA; Tortolani, DR; Purandare, AV; Tokarski, JS; Mussari, CP; Kamau, MG; Dodd, DS; Gavai, AV; O Malley, D; Huynh, TN; Vaccaro, W; Harikrishnan, LS Carbazole compounds useful as bromodomain inhibitors US Patent US10196387 Publication Date 2/5/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 |
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| Name: | Bromodomain-containing protein 4 |
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| Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | HUNK1 | Protein HUNK1 |
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| Type: | Protein |
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| Mol. Mass.: | 152264.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60885 |
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| Residue: | 1362 |
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| Sequence: | MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
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| BDBM243269 |
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| n/a |
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| Name | BDBM243269 |
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| Synonyms: | 3-(3,5-dimethyl-4- isoxazolyl)-7-((3-fluoro-1- piperidinyl)carbonyl)-9- (methylsulfonyl)-9H- carbazole-1-carboxamide | US10053454, Example 13 | US10196387, Example 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25FN4O5S |
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| Mol. Mass. | 512.553 |
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| SMILES | Cc1noc(C)c1-c1cc(C(N)=O)c2n(c3cc(ccc3c2c1)C(=O)N1CCCC(F)C1)S(C)(=O)=O |
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| Structure | 
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