Reaction Details |
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Target | Renin |
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Ligand | BDBM18274 |
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Substrate/Competitor | tetradecapeptide substrate, TDP |
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Meas. Tech. | In Vitro Enzyme Inhibition |
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pH | 7.2±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 13±n/a nM |
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Citation | Göschke, R; Stutz, S; Rasetti, V; Cohen, NC; Rahuel, J; Rigollier, P; Baum, HP; Forgiarini, P; Schnell, CR; Wagner, T; Gruetter, MG; Fuhrer, W; Schilling, W; Cumin, F; Wood, JM; Maibaum, J Novel 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin. J Med Chem50:4818-31 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM18274 |
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tetradecapeptide substrate, TDP |
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Name: | tetradecapeptide substrate, TDP |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 4775.39 |
Organism: | n/a |
Description: | n/a |
Residue: | 42 |
Sequence: | H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH
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