| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucocorticoid receptor |
|---|
| Ligand | BDBM19234 |
|---|
| Substrate/Competitor | BDBM18207 |
|---|
| Meas. Tech. | Competitive Receptor Binding Assay |
|---|
| pH | 8±n/a |
|---|
| Temperature | 277.15±n/a K |
|---|
| IC50 | 1.0±n/a nM |
|---|
| Citation |  Link, JT; Sorensen, B; Patel, J; Grynfarb, M; Goos-Nilsson, A; Wang, J; Fung, S; Wilcox, D; Zinker, B; Nguyen, P; Hickman, B; Schmidt, JM; Swanson, S; Tian, Z; Reisch, TJ; Rotert, G; Du, J; Lane, B; von Geldern, TW; Jacobson, PB Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators. J Med Chem48:5295-304 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Glucocorticoid receptor |
|---|
| Name: | Glucocorticoid receptor |
|---|
| Synonyms: | GCR_RAT | Glucocorticoid | Glucocorticoid Receptor (GR) | Glucocorticoid receptor | Grl | Nr3c1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 87556.83 |
|---|
| Organism: | RAT |
|---|
| Description: | Glucocorticoid 0 RAT::P06536 |
|---|
| Residue: | 795 |
|---|
| Sequence: | MDSKESLAPPGRDEVPGSLLGQGRGSVMDFYKSLRGGATVKVSASSPSVAAASQADSKQQ
RILLDFSKGSTSNVQQRQQQQQQQQQQQQQQQQQQQPDLSKAVSLSMGLYMGETETKVMG
NDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSVPENPKSSTSATGCATPTEKEFPKT
HSDASSEQQNRKSQTGTNGGSVKLYPTDQSTFDLLKDLEFSAGSPSKDTNESPWRSDLLI
DENLLSPLAGEDDPFLLEGNTNEDCKPLILPDTKPKIKDTGDTILSSPSSVALPQVKTEK
DDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTAS
LSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDSLTSLGALNFPGRSVFSNGYSSPGMRP
DVSSPPSSSSAATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRN
DCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENPNKTIVP
AALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIL
GLRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSGNLLCFAPDLIINEQRMSLPCMYDQ
CKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIV
KREGNSSQNWQRFYQLTKLLDSMHEVVENLLTYCFQTFLDKTMSIEFPEMLAEIITNQIP
KYSNGNIKKLLFHQK
|
|
|
|---|
| BDBM19234 |
|---|
| BDBM18207 |
|---|
| Name | BDBM19234 |
|---|
| Synonyms: | 4-{4-[3-(4-{[benzyl(3-methanesulfonamido-2-methylphenyl)amino]methyl}phenoxy)phenoxy]butanamido}butanoic acid | 4-{[4-(3-{4-[(Benzyl{2-methyl-3-[(methylsulfonyl)amino]-phenyl}amino)methyl]phenoxy}phenoxy)butanoyl]-amino}butanoic Acid | CHEMBL185265 | GR sulfonamide modulator, 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H41N3O7S |
|---|
| Mol. Mass. | 659.792 |
|---|
| SMILES | Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCCCC(=O)NCCCC(O)=O)c2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
