Reaction Details |
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Target | A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P] |
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Ligand | BDBM28312 |
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Substrate/Competitor | WAAG-3R |
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Meas. Tech. | ADAMTS-5 Enzyme Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 7300±n/a nM |
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Citation | Shiozaki, M; Maeda, K; Miura, T; Ogoshi, Y; Haas, J; Fryer, AM; Laird, ER; Littmann, NM; Andrews, SW; Josey, JA; Mimura, T; Shinozaki, Y; Yoshiuchi, H; Inaba, T Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett19:1575-80 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P] |
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Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P] |
Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 | ADAM-TS 11 | ADAMTS-5 (Aggrecanase-2) | ADAMTS11 | ADAMTS5 | ADMP-2 | ADMP2 | ATS5_HUMAN |
Type: | Metalloprotease |
Mol. Mass.: | 73728.14 |
Organism: | Homo sapiens (Human) |
Description: | Q9UNA0[262-930,L692P] |
Residue: | 669 |
Sequence: | SISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVL
GDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGM
ADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSS
ILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTF
GPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKY
YSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPC
PPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFS
PKVTDGTECRPYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK
SKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDI
NGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNS
VTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSA
FKQCLLKKC
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BDBM28312 |
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WAAG-3R |
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Name: | WAAG-3R |
Synonyms: | n/a |
Type: | Fluorescent peptide |
Mol. Mass.: | 1954.08 |
Organism: | n/a |
Description: | n/a |
Residue: | 19 |
Sequence: | Abz-TEGEARGSVI-Dap(Dnp)-KK
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