Ki Summary

Reaction Details

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Target

A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P]

Ligand

BDBM28317

Substrate/Competitor

WAAG-3R

Meas. Tech.

ADAMTS-5 Enzyme Inhibition Assay

7.5±n/a

Temperature

310.15±n/a K

IC50

1100±n/a nM

Citation

Shiozaki, M; Maeda, K; Miura, T; Ogoshi, Y; Haas, J; Fryer, AM; Laird, ER; Littmann, NM; Andrews, SW; Josey, JA; Mimura, T; Shinozaki, Y; Yoshiuchi, H; Inaba, T Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett19:1575-80 (2009) [PubMed] Article

More Info.:

Get all data from this article, Inhibition_Run data, Solution Info, Assay Method

A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P]

Name:

A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P]

Synonyms:

Type:

Metalloprotease

Mol. Mass.:

73728.14

Organism:

Homo sapiens (Human)

Description:

Q9UNA0[262-930,L692P]

Residue:

669

Sequence:

SISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVL
GDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGM
ADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSS
ILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTF
GPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKY
YSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPC
PPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFS
PKVTDGTECRPYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK
SKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDI
NGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNS
VTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSA
FKQCLLKKC

BDBM28317

WAAG-3R

Name:

WAAG-3R

Synonyms:

n/a

Type:

Fluorescent peptide

Mol. Mass.:

1954.08

Organism:

n/a

Description:

n/a

Residue:

Sequence:

Abz-TEGEARGSVI-Dap(Dnp)-KK