| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM220192 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1665145 (CHEMBL4014941) |
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| IC50 | 57±n/a nM |
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| Citation |  Kummer, DA; Cummings, MD; Abad, M; Barbay, J; Castro, G; Wolin, R; Kreutter, KD; Maharoof, U; Milligan, C; Nishimura, R; Pierce, J; Schalk-Hihi, C; Spurlino, J; Urbanski, M; Venkatesan, H; Wang, A; Woods, C; Xue, X; Edwards, JP; Fourie, AM; Leonard, K Identification and structure activity relationships of quinoline tertiary alcohol modulators of ROR?t. Bioorg Med Chem Lett27:2047-2057 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM220192 |
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| n/a |
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| Name | BDBM220192 |
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| Synonyms: | US9290476, 35A | US9290476, 35B | US9290476, 35C |
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| Type | Small organic molecule |
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| Emp. Form. | C31H24ClF3N6O2 |
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| Mol. Mass. | 605.009 |
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| SMILES | COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F |
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| Structure | 
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