Reaction Details |
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Target | Cytochrome P450 2E1 |
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Ligand | BDBM50272591 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1712614 (CHEMBL4122663) |
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IC50 | >50000±n/a nM |
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Citation | Miyazaki, H; Ikeda, Y; Sakurai, O; Miyake, T; Tsubota, R; Okabe, J; Kuroda, M; Hisada, Y; Yanagida, T; Yoneda, H; Tsukumo, Y; Tokunaga, S; Kawata, T; Ohashi, R; Fukuda, H; Kojima, K; Kannami, A; Kifuji, T; Sato, N; Idei, A; Iguchi, T; Sakairi, T; Moritani, Y Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism. Bioorg Med Chem Lett28:2055-2060 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2E1 |
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Name: | Cytochrome P450 2E1 |
Synonyms: | CP2E1_HUMAN | CYP2E | CYP2E1 | Cytochrome P450 2E1 (CYP2E1) |
Type: | Enzyme |
Mol. Mass.: | 56860.34 |
Organism: | Homo sapiens (Human) |
Description: | P05181 |
Residue: | 493 |
Sequence: | MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA
EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF
ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK
FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC
IPPRYKLCVIPRS
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BDBM50272591 |
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n/a |
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Name | BDBM50272591 |
Synonyms: | CHEMBL4128835 |
Type | Small organic molecule |
Emp. Form. | C24H28Cl2N2O2 |
Mol. Mass. | 447.397 |
SMILES | Cl.Cl.C[C@@H](N[C@H]1CCN(C1)c1ccc(CC(O)=O)cc1)c1cccc2ccccc12 |r| |
Structure |
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