Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
---|
Ligand | BDBM50187693 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1728696 (CHEMBL4143974) |
---|
IC50 | 307±n/a nM |
---|
Citation | Kuttruff, CA; Ferrara, M; Bretschneider, T; Hoerer, S; Handschuh, S; Nosse, B; Romig, H; Nicklin, P; Roth, GJ Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo. ACS Med Chem Lett8:1252-1257 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
---|
Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
Synonyms: | 3.1.4.39 | Atx | Autotaxin | E-NPP 2 | ENPP2_RAT | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enpp2 | Extracellular lysophospholipase D | LysoPLD | Npps2 |
Type: | PROTEIN |
Mol. Mass.: | 101590.86 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_116829 |
Residue: | 887 |
Sequence: | MARQGCLGSFQVISLFTFAISVNICLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKG
RCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCS
EDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKK
GSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDAS
FHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERP
SVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHG
MEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIANLTCKKPDQHF
KPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKV
NSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFR
PTMPDEVSRPNYPGIMYLQSEFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEAETGKFRG
SKHENKKNLNGSVEPRKERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTI
SKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDA
FLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQY
VEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWV
EELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI
|
|
|
BDBM50187693 |
---|
n/a |
---|
Name | BDBM50187693 |
Synonyms: | CHEMBL3186509 |
Type | Small organic molecule |
Emp. Form. | C22H21Cl2N3O5 |
Mol. Mass. | 478.325 |
SMILES | Clc1cc(Cl)cc(COC(=O)N2CCN(CCC(=O)c3ccc4[nH]c(=O)oc4c3)CC2)c1 |
Structure |
|