| Reaction Details |
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 | Report a problem with these data |
| Target | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Ligand | BDBM50467491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1796365 (CHEMBL4268482) |
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| IC50 | 99±n/a nM |
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| Citation |  Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Discovery of furyl/thienyl ?-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect. Eur J Med Chem158:767-780 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A |
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| Type: | Enzyme |
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| Mol. Mass.: | 104751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HCR9 |
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| Residue: | 933 |
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| Sequence: | MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
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| BDBM50467491 |
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| n/a |
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| Name | BDBM50467491 |
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| Synonyms: | CHEMBL4289291 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N3O3 |
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| Mol. Mass. | 363.4097 |
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| SMILES | [H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)N(CC)C2=O)c1ccc(CC)o1 |r| |
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| Structure | 
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