| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Ligand | BDBM50472198 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_155726 (CHEMBL760760) |
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| IC50 | 320±n/a nM |
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| Citation |  Christensen, SB; Guider, A; Forster, CJ; Gleason, JG; Bender, PE; Karpinski, JM; DeWolf, WE; Barnette, MS; Underwood, DC; Griswold, DE; Cieslinski, LB; Burman, M; Bochnowicz, S; Osborn, RR; Manning, CD; Grous, M; Hillegas, LM; Bartus, JO; Ryan, MD; Eggleston, DS; Haltiwanger, RC; Torphy, TJ 1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma. J Med Chem41:821-35 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60038.21 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 536 |
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| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
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| BDBM50472198 |
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| n/a |
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| Name | BDBM50472198 |
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| Synonyms: | CHEMBL354447 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N2O3 |
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| Mol. Mass. | 380.48 |
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| SMILES | COc1ccc(cc1OC1CCCC1)C1CN(Cc2ccc(N)cc2)C(=O)C1 |
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| Structure | 
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