| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50476387 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_437168 (CHEMBL906565) |
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| IC50 | 5400±n/a nM |
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| Citation |  Mackman, RL; Zhang, L; Prasad, V; Boojamra, CG; Douglas, J; Grant, D; Hui, H; Kim, CU; Laflamme, G; Parrish, J; Stoycheva, AD; Swaminathan, S; Wang, K; Cihlar, T Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs. Bioorg Med Chem15:5519-28 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50476387 |
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| n/a |
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| Name | BDBM50476387 |
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| Synonyms: | CHEMBL229111 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15N2O7P |
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| Mol. Mass. | 306.2091 |
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| SMILES | Cc1cn([C@H]2CC[C@@H](OCP(O)(O)=O)O2)c(=O)[nH]c1=O |
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| Structure | 
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