Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Integrase |
---|
Ligand | BDBM50478737 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_504751 (CHEMBL990225) |
---|
IC50 | 28000±n/a nM |
---|
Citation | Singh, SB; Jayasuriya, H; Salituro, GM; Zink, DL; Shafiee, A; Heimbuch, B; Silverman, KC; Lingham, RB; Genilloud, O; Teran, A; Vilella, D; Felock, P; Hazuda, D The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I. J Nat Prod64:874-82 (2001) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Integrase |
---|
Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
|
|
|
BDBM50478737 |
---|
n/a |
---|
Name | BDBM50478737 |
Synonyms: | CHEMBL506051 |
Type | Small organic molecule |
Emp. Form. | C37H33Cl2N5O9 |
Mol. Mass. | 762.592 |
SMILES | CN[C@@H](Cc1ccc(Oc2cc3cc(c2O)-c2cccc4c(C[C@@H](N)C(=O)N[C@H](c5cc(Cl)c(O)c(Cl)c5)C(=O)N[C@H]3C(O)=O)c[nH]c24)cc1)C(O)=O |r| |
Structure |
|