| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50485916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_878296 (CHEMBL2185924) |
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| IC50 | >111000±n/a nM |
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| Citation |  Zeng, LF; Wang, Y; Kazemi, R; Xu, S; Xu, ZL; Sanchez, TW; Yang, LM; Debnath, B; Odde, S; Xie, H; Zheng, YT; Ding, J; Neamati, N; Long, YQ Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties. J Med Chem55:9492-509 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50485916 |
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| n/a |
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| Name | BDBM50485916 |
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| Synonyms: | CHEMBL2180596 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20BrFN4O |
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| Mol. Mass. | 479.344 |
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| SMILES | C[C@@H](Nc1c(nc(Br)c2cccnc12)C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| |
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| Structure | 
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