Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Mitogen-activated protein kinase 11 |
---|
Ligand | BDBM50492395 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_972027 (CHEMBL2405978) |
---|
IC50 | 6799±n/a nM |
---|
Citation | Wrobleski, ST; Lin, S; Dhar, TG; Dyckman, AJ; Li, T; Pitt, S; Zhang, R; Fan, Y; Doweyko, AM; Tokarski, JS; Kish, KF; Kiefer, SE; Sack, JS; Newitt, JA; Witmer, MR; McKinnon, M; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K The identification of novel p38? isoform selective kinase inhibitors having an unprecedented p38? binding mode. Bioorg Med Chem Lett23:4120-6 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Mitogen-activated protein kinase 11 |
---|
Name: | Mitogen-activated protein kinase 11 |
Synonyms: | MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41351.73 |
Organism: | Homo sapiens (Human) |
Description: | gi_20128774 |
Residue: | 364 |
Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
|
|
|
BDBM50492395 |
---|
n/a |
---|
Name | BDBM50492395 |
Synonyms: | CHEMBL2401996 |
Type | Small organic molecule |
Emp. Form. | C21H19N3O2S |
Mol. Mass. | 377.459 |
SMILES | Cc1ccc(cc1NC(=O)c1ccc(s1)-c1ccccn1)C(=O)NC1CC1 |
Structure |
|