| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 11 |
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| Ligand | BDBM50492374 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_972027 (CHEMBL2405978) |
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| IC50 | 265±n/a nM |
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| Citation |  Wrobleski, ST; Lin, S; Dhar, TG; Dyckman, AJ; Li, T; Pitt, S; Zhang, R; Fan, Y; Doweyko, AM; Tokarski, JS; Kish, KF; Kiefer, SE; Sack, JS; Newitt, JA; Witmer, MR; McKinnon, M; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K The identification of novel p38? isoform selective kinase inhibitors having an unprecedented p38? binding mode. Bioorg Med Chem Lett23:4120-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 11 |
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| Name: | Mitogen-activated protein kinase 11 |
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| Synonyms: | MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41351.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_20128774 |
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| Residue: | 364 |
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| Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
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| BDBM50492374 |
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| n/a |
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| Name | BDBM50492374 |
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| Synonyms: | CHEMBL2401983 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19ClN2O2S |
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| Mol. Mass. | 410.916 |
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| SMILES | Cc1ccc(cc1NC(=O)c1ccc(s1)-c1ccccc1Cl)C(=O)NC1CC1 |
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| Structure | 
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