| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Ligand | BDBM50500539 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1546423 (CHEMBL3748978) |
|---|
| IC50 | 1700±n/a nM |
|---|
| Citation |  Li, Y; Woo, J; Chmielecki, J; Xia, CQ; Liao, M; Chuang, BC; Yang, JJ; Guan, MY; Plesescu, M; Prakash, SR Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles. Bioorg Med Chem Lett26:551-555 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
|---|
| Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
|---|
| Mol. Mass.: | 72329.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UNQ0 |
|---|
| Residue: | 655 |
|---|
| Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
|
|
|
|---|
| BDBM50500539 |
|---|
| n/a |
|---|
| Name | BDBM50500539 |
|---|
| Synonyms: | CHEMBL3746825 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H27N3O4 |
|---|
| Mol. Mass. | 385.4568 |
|---|
| SMILES | [H][C@]12Cc3c([nH]c4cc(OC)c(OC)cc34)[C@H](CC(C)C)N1C(=O)[C@H](C)NC2=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
