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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50502585 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1808007 (CHEMBL4307366) | ||
| EC50 | 12±n/a nM | ||
| Citation |  Harrison, TJ; Bauer, D; Berdichevsky, A; Chen, X; Duvadie, R; Hoogheem, B; Hatsis, P; Liu, Q; Mao, J; Miduturu, V; Rocheford, E; Zecri, F; Zessis, R; Zheng, R; Zhu, Q; Streeper, R; Patel, SJ Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor. ACS Med Chem Lett10:1128-1133 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
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| BDBM50502585 | |||
| n/a | |||
| Name | BDBM50502585 | ||
| Synonyms: | CHEMBL4446248 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H29N3O4 | ||
| Mol. Mass. | 459.5369 | ||
| SMILES | OC(=O)CC12CCC(CC1)(CO2)c1ccc(cc1)-c1ccc(Nc2nnc(o2)C2CCC2)cc1 |(78.38,-14.6,;77.05,-15.37,;77.05,-16.91,;75.72,-14.6,;74.38,-15.37,;74.38,-16.91,;73.06,-17.68,;71.72,-16.91,;71.71,-15.38,;73.05,-14.6,;72.47,-15.57,;73.56,-16.66,;70.39,-17.69,;70.4,-19.23,;69.07,-20,;67.73,-19.23,;67.72,-17.7,;69.05,-16.92,;66.4,-20.01,;66.41,-21.55,;65.07,-22.32,;63.75,-21.55,;62.41,-22.32,;61.08,-21.56,;59.67,-22.19,;58.64,-21.05,;59.41,-19.71,;60.91,-20.03,;58.78,-18.31,;59.33,-16.87,;57.9,-16.32,;57.35,-17.76,;63.73,-20.02,;65.06,-19.24,)| | ||
| Structure | 
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