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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50502591 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1807990 (CHEMBL4307349) | ||
| IC50 | 120±n/a nM | ||
| Citation |  Harrison, TJ; Bauer, D; Berdichevsky, A; Chen, X; Duvadie, R; Hoogheem, B; Hatsis, P; Liu, Q; Mao, J; Miduturu, V; Rocheford, E; Zecri, F; Zessis, R; Zheng, R; Zhu, Q; Streeper, R; Patel, SJ Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor. ACS Med Chem Lett10:1128-1133 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50502591 | |||
| n/a | |||
| Name | BDBM50502591 | ||
| Synonyms: | CHEMBL4563171 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28N4O4 | ||
| Mol. Mass. | 460.5249 | ||
| SMILES | OC(=O)CC12CCC(CC1)(CO2)c1ccc(cc1)-c1ccc(Nc2nnc(o2)C2CCC2)cn1 |(78.4,-2.43,;77.06,-3.2,;77.06,-4.74,;75.73,-2.43,;74.4,-3.2,;74.39,-4.74,;73.07,-5.51,;71.73,-4.74,;71.72,-3.2,;73.06,-2.43,;72.49,-3.4,;73.57,-4.49,;70.4,-5.51,;70.41,-7.06,;69.08,-7.83,;67.74,-7.06,;67.73,-5.53,;69.06,-4.75,;66.42,-7.84,;65.07,-7.07,;63.75,-7.84,;63.76,-9.38,;62.42,-10.15,;61.09,-9.38,;59.68,-10.02,;58.65,-8.88,;59.42,-7.54,;60.92,-7.86,;58.79,-6.14,;59.34,-4.7,;57.91,-4.15,;57.36,-5.59,;65.09,-10.15,;66.42,-9.38,)| | ||
| Structure | 
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