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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50502595 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1807990 (CHEMBL4307349) | ||
| IC50 | 9.0±n/a nM | ||
| Citation |  Harrison, TJ; Bauer, D; Berdichevsky, A; Chen, X; Duvadie, R; Hoogheem, B; Hatsis, P; Liu, Q; Mao, J; Miduturu, V; Rocheford, E; Zecri, F; Zessis, R; Zheng, R; Zhu, Q; Streeper, R; Patel, SJ Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor. ACS Med Chem Lett10:1128-1133 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50502595 | |||
| n/a | |||
| Name | BDBM50502595 | ||
| Synonyms: | CHEMBL4554065 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H28N4O2S | ||
| Mol. Mass. | 448.58 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc(Nc2nnc(s2)C2CCC2)cn1 |r,wU:7.10,wD:4.3,(51.91,-2.96,;50.57,-3.73,;50.58,-5.27,;49.24,-2.97,;47.91,-3.74,;46.57,-2.97,;45.23,-3.74,;45.24,-5.28,;46.58,-6.05,;47.91,-5.28,;43.92,-6.05,;43.92,-7.59,;42.59,-8.37,;41.25,-7.6,;41.25,-6.06,;42.57,-5.29,;39.93,-8.37,;38.58,-7.6,;37.26,-8.38,;37.27,-9.92,;35.94,-10.69,;34.6,-9.92,;33.19,-10.55,;32.16,-9.41,;32.93,-8.07,;34.44,-8.39,;32.3,-6.66,;32.85,-5.23,;31.41,-4.68,;30.86,-6.12,;38.6,-10.68,;39.93,-9.91,)| | ||
| Structure | 
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