| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50054496 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_212717 (CHEMBL818176) |
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| IC50 | >2500±n/a nM |
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| Citation |  Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Håkanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties. J Med Chem39:4531-6 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50054496 |
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| n/a |
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| Name | BDBM50054496 |
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| Synonyms: | (R)-N-((S)-3-Carbamimidoyl-2-hydroxy-cyclohexyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionamide | CHEMBL342709 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H35N5O5S |
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| Mol. Mass. | 493.62 |
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| SMILES | C[C@@H](N1CCCC[C@H](NS(=O)(=O)Cc2ccccc2)C1=O)C(=O)N[C@H]1CCCC(C1O)C(N)=N |
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| Structure | 
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