Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50504834 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1816837 (CHEMBL4316411) |
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Ki | 121±n/a nM |
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Citation | Staro?, J; Kurczab, R; Warszycki, D; Sata?a, G; Krawczyk, M; Bugno, R; Lenda, T; Popik, P; Hogendorf, AS; Hogendorf, A; Dubiel, K; Mat?oka, M; Moszczy?ski-P?tkowski, R; Pieczykolan, J; Wieczorek, M; Zajdel, P; Bojarski, AJ Virtual screening-driven discovery of dual 5-HT Eur J Med Chem185:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50504834 |
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n/a |
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Name | BDBM50504834 |
Synonyms: | CHEMBL4591410 |
Type | Small organic molecule |
Emp. Form. | C19H20N4O2 |
Mol. Mass. | 336.3877 |
SMILES | COc1ccc2[nH]cc(CCNCc3ccc(o3)-c3cn[nH]c3)c2c1 |
Structure |
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