| Reaction Details |
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 | Report a problem with these data |
| Target | Protease |
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| Ligand | BDBM50504881 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1816866 (CHEMBL4316440) |
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| IC50 | 20±n/a nM |
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| Citation |  Zhu, M; Ma, L; Zhou, H; Dong, B; Wang, Y; Wang, Z; Zhou, J; Zhang, G; Wang, J; Liang, C; Cen, S; Wang, Y Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants. Eur J Med Chem185:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protease |
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| Name: | Protease |
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| Synonyms: | n/a |
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| Type: | Enzyme |
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| Mol. Mass.: | 10904.79 |
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| Organism: | Human immunodeficiency virus 1 (HIV-1) |
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| Description: | Q9YQ12 |
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| Residue: | 99 |
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| Sequence: | PQITLWQRPFVTIKIEGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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| BDBM50504881 |
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| n/a |
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| Name | BDBM50504881 |
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| Synonyms: | CHEMBL4574190 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33N5O6S |
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| Mol. Mass. | 543.635 |
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| SMILES | CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)Cn1ccc(=O)[nH]c1=O)S(=O)(=O)c1ccc(N)cc1 |r| |
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| Structure | 
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