| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM50506498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1826010 (CHEMBL4325774) |
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| IC50 | 200±n/a nM |
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| Citation |  Tora, G; Kim, SH; Pi, Z; Johnson, JA; Jiang, J; Phillips, M; Lloyd, J; Abell, LM; Lu, H; Locke, G; Adam, LP; Taylor, DS; Yin, X; Behnia, K; Zhao, L; Yang, R; Basso, M; Caporuscio, C; Chen, AY; Liu, E; Kirshgessner, T; Onorato, JM; Ryan, C; Traeger, SC; Gordon, D; Wexler, RR; Finlay, HJ Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo. J Med Chem63:1660-1670 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg |
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| Type: | Protein |
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| Mol. Mass.: | 56643.58 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q9WVG5 |
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| Residue: | 500 |
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| Sequence: | MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPE
QEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHID
IYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
SRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNN
SGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVA
HSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWF
HKCQDGWKMKNKTSPFVNLA
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| BDBM50506498 |
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| n/a |
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| Name | BDBM50506498 |
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| Synonyms: | CHEMBL4581886 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13FN6O5S2 |
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| Mol. Mass. | 488.472 |
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| SMILES | NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2cc(c(F)cc2s1)-c1ccc2C(=O)NCc2c1 |
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| Structure | 
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