| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl hydroxylase EGLN2 |
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| Ligand | BDBM50507408 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1829979 (CHEMBL4329853) |
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| IC50 | 2.4±n/a nM |
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| Citation |  Liu, P; Wang, L; DuBois, BG; Colandrea, VJ; Liu, R; Cai, J; Du, X; Quan, W; Morris, W; Bai, J; Bishwokarma, B; Cheng, M; Piesvaux, J; Ray, K; Alpert, C; Chiu, CS; Zielstorff, M; Metzger, JM; Yang, L; Leung, D; Alleyne, C; Vincent, SH; Pucci, V; Li, X; Crespo, A; Stickens, D; Hale, JJ; Ujjainwalla, F; Sinz, CJ Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia. ACS Med Chem Lett9:1193-1198 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl hydroxylase EGLN2 |
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| Name: | Prolyl hydroxylase EGLN2 |
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| Synonyms: | EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1) |
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| Type: | Protein |
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| Mol. Mass.: | 43657.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96KS0 |
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| Residue: | 407 |
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| Sequence: | MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
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| BDBM50507408 |
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| n/a |
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| Name | BDBM50507408 |
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| Synonyms: | CHEMBL4561977 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15F3N2O7 |
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| Mol. Mass. | 428.3161 |
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| SMILES | OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2ccc(OC(F)(F)F)cc2)c1=O |
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| Structure | 
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