| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
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| Ligand | BDBM50509149 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1837711 (CHEMBL4337844) |
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| EC50 | 76±n/a nM |
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| Citation |  Hao, J; Beck, JP; Schaus, JM; Krushinski, JH; Chen, Q; Beadle, CD; Vidal, P; Reinhard, MR; Dressman, BA; Massey, SM; Boulet, SL; Cohen, MP; Watson, BM; Tupper, D; Gardinier, KM; Myers, J; Johansson, AM; Richardson, J; Richards, DS; Hembre, EJ; Remick, DM; Coates, DA; Bhardwaj, RM; Diseroad, BA; Bender, D; Stephenson, G; Wolfangel, CD; Diaz, N; Getman, BG; Wang, XS; Heinz, BA; Cramer, JW; Zhou, X; Maren, DL; Falcone, JF; Wright, RA; Mitchell, SN; Carter, G; Yang, CR; Bruns, RF; Svensson, KA Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1 J Med Chem62:8711-8732 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(1A) dopamine receptor |
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| Name: | D(1A) dopamine receptor |
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| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A |
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| Type: | Enzyme |
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| Mol. Mass.: | 49303.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21728 |
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| Residue: | 446 |
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| Sequence: | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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| BDBM50509149 |
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| n/a |
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| Name | BDBM50509149 |
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| Synonyms: | CHEMBL3421836 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27Cl2NO3 |
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| Mol. Mass. | 436.371 |
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| SMILES | C[C@@H]1N([C@@H](CO)Cc2c(CC(C)(C)O)cccc12)C(=O)Cc1c(Cl)cccc1Cl |r| |
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| Structure | 
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