Reaction Details |
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Target | Oxidized purine nucleoside triphosphate hydrolase |
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Ligand | BDBM50511446 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1844828 (CHEMBL4345255) |
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IC50 | 13±n/a nM |
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Citation | Farand, J; Kropf, JE; Blomgren, P; Xu, J; Schmitt, AC; Newby, ZE; Wang, T; Murakami, E; Barauskas, O; Sudhamsu, J; Feng, JY; Niedziela-Majka, A; Schultz, BE; Schwartz, K; Viatchenko-Karpinski, S; Kornyeyev, D; Kashishian, A; Fan, P; Chen, X; Lansdon, EB; Ports, MO; Currie, KS; Watkins, WJ; Notte, GT Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation. ACS Med Chem Lett11:358-364 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Oxidized purine nucleoside triphosphate hydrolase |
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Name: | Oxidized purine nucleoside triphosphate hydrolase |
Synonyms: | 2-hydroxy-dATP diphosphatase | 3.6.1.- | 3.6.1.56 | 7,8-dihydro-8-oxoguanine triphosphatase | 8-oxo-dGTPase | 8ODP_HUMAN | MTH1 | Methylated purine nucleoside triphosphate hydrolase | MutT homolog 1 protein (MTH1) | NUDT1 | Nucleoside diphosphate-linked moiety X motif 1 | Nudix motif 1 | Oxidized purine nucleoside triphosphate hydrolase [42-197] |
Type: | Protein |
Mol. Mass.: | 22514.81 |
Organism: | Homo sapiens (Human) |
Description: | P36639 |
Residue: | 156 |
Sequence: | MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLT
VDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDD
SYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
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BDBM50511446 |
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n/a |
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Name | BDBM50511446 |
Synonyms: | CHEMBL4445709 |
Type | Small organic molecule |
Emp. Form. | C14H11Cl2N3O |
Mol. Mass. | 308.163 |
SMILES | COc1cc(-c2cccc(Cl)c2Cl)c2nc(N)[nH]c2c1 |
Structure |
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