| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP] cytoplasmic |
|---|
| Ligand | BDBM383893 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1859386 (CHEMBL4360242) |
|---|
| IC50 | 9.0±n/a nM |
|---|
| Citation |  Lin, J; Lu, W; Caravella, JA; Campbell, AM; Diebold, RB; Ericsson, A; Fritzen, E; Gustafson, GR; Lancia, DR; Shelekhin, T; Wang, Z; Castro, J; Clarke, A; Gotur, D; Josephine, HR; Katz, M; Diep, H; Kershaw, M; Yao, L; Kauffman, G; Hubbs, SE; Luke, GP; Toms, AV; Wang, L; Bair, KW; Barr, KJ; Dinsmore, C; Walker, D; Ashwell, S Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. J Med Chem62:6575-6596 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Isocitrate dehydrogenase [NADP] cytoplasmic |
|---|
| Name: | Isocitrate dehydrogenase [NADP] cytoplasmic |
|---|
| Synonyms: | Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46661.29 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75874 |
|---|
| Residue: | 414 |
|---|
| Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
|
|
|
|---|
| BDBM383893 |
|---|
| n/a |
|---|
| Name | BDBM383893 |
|---|
| Synonyms: | US10280150, Cmpd No I-176 | US10550099, Compound I-176 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18ClN5O2 |
|---|
| Mol. Mass. | 395.842 |
|---|
| SMILES | COc1nc(N[C@@H](C)c2cc3cc(Cl)c(cc3[nH]c2=O)C2CC2)ncc1C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
