| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM50521234 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1883780 (CHEMBL4385279) |
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| IC50 | 160±n/a nM |
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| Citation |  Johnson, JA; Tora, G; Pi, Z; Phillips, M; Yin, X; Yang, R; Zhao, L; Chen, AY; Taylor, DS; Basso, M; Rose, A; Behnia, K; Onorato, J; Chen, XQ; Abell, LM; Lu, H; Locke, G; Caporuscio, C; Galella, M; Adam, LP; Gordon, D; Wexler, RR; Finlay, HJ Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase. ACS Med Chem Lett9:1263-1268 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
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| Type: | Protein |
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| Mol. Mass.: | 56805.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5X9 |
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| Residue: | 500 |
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| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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| BDBM50521234 |
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| n/a |
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| Name | BDBM50521234 |
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| Synonyms: | CHEMBL4536805 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N5O5S2 |
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| Mol. Mass. | 497.547 |
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| SMILES | CC1(Cc2nnc(o2)C(c2nc3ccc(cc3s2)-c2ccccc2)S(C)(=O)=O)NC(=O)NC1=O |
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| Structure | 
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