Reaction Details |
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Target | Methionine aminopeptidase 2 |
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Ligand | BDBM64987 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1895047 (CHEMBL4397082) |
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IC50 | 55±n/a nM |
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Citation | Heinrich, T; Seenisamy, J; Blume, B; Bomke, J; Calderini, M; Eckert, U; Friese-Hamim, M; Kohl, R; Lehmann, M; Leuthner, B; Musil, D; Rohdich, F; Zenke, FT Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors. J Med Chem62:5025-5039 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Methionine aminopeptidase 2 |
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Name: | Methionine aminopeptidase 2 |
Synonyms: | Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67 |
Type: | Enzyme |
Mol. Mass.: | 52884.45 |
Organism: | Homo sapiens (Human) |
Description: | P50579 |
Residue: | 478 |
Sequence: | MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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BDBM64987 |
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n/a |
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Name | BDBM64987 |
Synonyms: | 5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HYDROXY-5-NITROQUINOLINE | MLS000069750 | SMR000059036 | cid_19910 | nitroxoline |
Type | Small organic molecule |
Emp. Form. | C9H6N2O3 |
Mol. Mass. | 190.1555 |
SMILES | Oc1ccc([N+]([O-])=O)c2cccnc12 |
Structure |
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