| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 2 |
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| Ligand | BDBM50531156 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1914455 (CHEMBL4417038) |
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| IC50 | 52±n/a nM |
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| Citation |  Heinrich, T; Seenisamy, J; Becker, F; Blume, B; Bomke, J; Dietz, M; Eckert, U; Friese-Hamim, M; Gunera, J; Hansen, K; Leuthner, B; Musil, D; Pfalzgraf, J; Rohdich, F; Siegl, C; Spuck, D; Wegener, A; Zenke, FT Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor J Med Chem62:11119-11134 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 2 |
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| Name: | Methionine aminopeptidase 2 |
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| Synonyms: | Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67 |
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| Type: | Enzyme |
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| Mol. Mass.: | 52884.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50579 |
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| Residue: | 478 |
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| Sequence: | MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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| BDBM50531156 |
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| n/a |
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| Name | BDBM50531156 |
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| Synonyms: | CHEMBL4522216 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19F2N3O4 |
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| Mol. Mass. | 415.3901 |
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| SMILES | O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cccc(F)c1F |r| |
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| Structure | 
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