| Reaction Details |
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 | Report a problem with these data |
| Target | Proton-coupled folate transporter |
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| Ligand | BDBM50534429 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1928968 (CHEMBL4432144) |
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| IC50 | 82±n/a nM |
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| Citation |  Golani, LK; Wallace-Povirk, A; Deis, SM; Wong, J; Ke, J; Gu, X; Raghavan, S; Wilson, MR; Li, X; Polin, L; de Waal, PW; White, K; Kushner, J; O'Connor, C; Hou, Z; Xu, HE; Melcher, K; Dann, CE; Matherly, LH; Gangjee, A Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem59:7856-76 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proton-coupled folate transporter |
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| Name: | Proton-coupled folate transporter |
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| Synonyms: | G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49782.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469597 |
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| Residue: | 459 |
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| Sequence: | MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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| BDBM50534429 |
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| n/a |
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| Name | BDBM50534429 |
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| Synonyms: | CHEMBL4444011 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N6O7 |
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| Mol. Mass. | 484.462 |
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| SMILES | CC(=O)N(CCc1cc2c(nc(N)[nH]c2=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| |
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| Structure | 
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