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TargetProton-coupled folate transporter
LigandBDBM50534429
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1928968 (CHEMBL4432144)
IC50 82±n/a nM
Citation Golani, LKWallace-Povirk, ADeis, SMWong, JKe, JGu, XRaghavan, SWilson, MRLi, XPolin, Lde Waal, PWWhite, KKushner, JO'Connor, CHou, ZXu, HEMelcher, KDann, CEMatherly, LHGangjee, A Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem59:7856-76 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proton-coupled folate transporter
Name:Proton-coupled folate transporter
Synonyms:G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1
Type:PROTEIN
Mol. Mass.:49782.13
Organism:Homo sapiens (Human)
Description:ChEMBL_1469597
Residue:459
Sequence:
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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  Blast E-value cutoff:
BDBM50534429
n/a
NameBDBM50534429
Synonyms:CHEMBL4444011
TypeSmall organic molecule
Emp. Form.C22H24N6O7
Mol. Mass.484.462
SMILESCC(=O)N(CCc1cc2c(nc(N)[nH]c2=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r|
Structure
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