| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50535402 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1930403 (CHEMBL4433654) |
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| IC50 | 12780±n/a nM |
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| Citation |  De Simone, A; La Pietra, V; Betari, N; Petragnani, N; Conte, M; Daniele, S; Pietrobono, D; Martini, C; Petralla, S; Casadei, R; Davani, L; Frabetti, F; Russomanno, P; Novellino, E; Montanari, S; Tumiatti, V; Ballerini, P; Sarno, F; Nebbioso, A; Altucci, L; Monti, B; Andrisano, V; Milelli, A Discovery of the First-in-Class GSK-3?/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease. ACS Med Chem Lett10:469-474 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50535402 |
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| n/a |
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| Name | BDBM50535402 |
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| Synonyms: | CHEMBL4449010 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18N4O4S |
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| Mol. Mass. | 350.393 |
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| SMILES | ONC(=O)CCCCCNC(=S)Nc1ccc2C(=O)NC(=O)c2c1 |
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| Structure | 
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