Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM50535401 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1930401 (CHEMBL4433652) |
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IC50 | 19960±n/a nM |
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Citation | De Simone, A; La Pietra, V; Betari, N; Petragnani, N; Conte, M; Daniele, S; Pietrobono, D; Martini, C; Petralla, S; Casadei, R; Davani, L; Frabetti, F; Russomanno, P; Novellino, E; Montanari, S; Tumiatti, V; Ballerini, P; Sarno, F; Nebbioso, A; Altucci, L; Monti, B; Andrisano, V; Milelli, A Discovery of the First-in-Class GSK-3?/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease. ACS Med Chem Lett10:469-474 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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BDBM50535401 |
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n/a |
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Name | BDBM50535401 |
Synonyms: | CHEMBL4443876 |
Type | Small organic molecule |
Emp. Form. | C12H12N4O4S |
Mol. Mass. | 308.313 |
SMILES | ONC(=O)CCNC(=S)Nc1ccc2C(=O)NC(=O)c2c1 |
Structure |
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