| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
|---|
| Ligand | BDBM50537742 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1970498 |
|---|
| IC50 | 13770±n/a nM |
|---|
| Citation |  Zhou, H; McGowan, MA; Lipford, K; Christopher, M; Fradera, X; Witter, D; Lesburg, CA; Li, C; Methot, JL; Lampe, J; Achab, A; Shaffer, L; Goldenblatt, P; Shah, S; Bass, A; Schroeder, G; Chen, D; Zeng, H; Augustin, MA; Katz, JD Discovery and optimization of heteroaryl piperazines as potent and selective PI3K? inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingosine kinase 1 |
|---|
| Name: | Sphingosine kinase 1 |
|---|
| Synonyms: | SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42521.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NYA1 |
|---|
| Residue: | 384 |
|---|
| Sequence: | MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
|
|
|
|---|
| BDBM50537742 |
|---|
| n/a |
|---|
| Name | BDBM50537742 |
|---|
| Synonyms: | CHEMBL4634634 | US11179389, Compound 1-14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N7O |
|---|
| Mol. Mass. | 365.4322 |
|---|
| SMILES | C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
