| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 3 |
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| Ligand | BDBM210300 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1991911 (CHEMBL4625646) |
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| IC50 | 760±n/a nM |
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| Citation |  Nair, S; Kumar, SR; Paidi, VR; Sistla, R; Kantheti, D; Polimera, SR; Thangavel, S; Mukherjee, AJ; Das, M; Bhide, RS; Pitts, WJ; Murugesan, N; Dudhgoankar, S; Nagar, J; Subramani, S; Mazumder, D; Carman, JA; Holloway, DA; Li, X; Fereshteh, MP; Ruepp, S; Palanisamy, K; Mariappan, TT; Maddi, S; Saxena, A; Elzinga, P; Chimalakonda, A; Ruan, Q; Ghosh, K; Bose, S; Sack, J; Yan, C; Kiefer, SE; Xie, D; Newitt, JA; Saravanakumar, SP; Rampulla, RA; Barrish, JC; Carter, PH; Hynes, J Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis. ACS Med Chem Lett11:1402-1409 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 3 |
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| Name: | Interleukin-1 receptor-associated kinase 3 |
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| Synonyms: | IL-1 receptor-associated kinase M | IRAK-3 | IRAK-M | IRAK3 | IRAK3_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67767.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_101055 |
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| Residue: | 596 |
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| Sequence: | MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK
YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG
FPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY
RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI
YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL
LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF
GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC
LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE
DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE
ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
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| BDBM210300 |
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| n/a |
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| Name | BDBM210300 |
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| Synonyms: | US9546153, ex. 367 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25F2N7O2 |
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| Mol. Mass. | 433.455 |
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| SMILES | CC(C)Nc1cc(Nc2nc3ccnn3cc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O |r| |
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| Structure | 
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