| Reaction Details |
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 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
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| Ligand | BDBM489157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2017127 (CHEMBL4670705) |
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| IC50 | 24±n/a nM |
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| Citation |  Rai, G; Urban, DJ; Mott, BT; Hu, X; Yang, SM; Benavides, GA; Johnson, MS; Squadrito, GL; Brimacombe, KR; Lee, TD; Cheff, DM; Zhu, H; Henderson, MJ; Pohida, K; Sulikowski, GA; Dranow, DM; Kabir, M; Shah, P; Padilha, E; Tao, D; Fang, Y; Christov, PP; Kim, K; Jana, S; Muttil, P; Anderson, T; Kunda, NK; Hathaway, HJ; Kusewitt, DF; Oshima, N; Cherukuri, M; Davies, DR; Norenberg, JP; Sklar, LA; Moore, WJ; Dang, CV; Stott, GM; Neckers, L; Flint, AJ; Darley-Usmar, VM; Simeonov, A; Waterson, AG; Jadhav, A; Hall, MD; Maloney, DJ Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J Med Chem63:10984-11011 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| L-lactate dehydrogenase A chain |
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| Name: | L-lactate dehydrogenase A chain |
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| Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
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| Type: | Protein |
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| Mol. Mass.: | 36694.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00338::PDB Code: 4ajp |
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| Residue: | 332 |
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| Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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| BDBM489157 |
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| n/a |
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| Name | BDBM489157 |
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| Synonyms: | 2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(pent-1- yn-1-yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid | US10961200, Compound 539 | US11247971, Cmpd ID 539 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H26F2N4O4S2 |
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| Mol. Mass. | 596.668 |
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| SMILES | CCCC#Cc1cc(ccc1F)-c1nn(c(CC2CC2)c1Cc1ccc(c(F)c1)S(N)(=O)=O)-c1nc(cs1)C(O)=O |
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| Structure | 
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