| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-8 |
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| Ligand | BDBM50554369 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2049561 (CHEMBL4704260) |
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| IC50 | 99±n/a nM |
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| Citation |  Zhan, W; Singh, PK; Ban, Y; Qing, X; Ah Kioon, MD; Fan, H; Zhao, Q; Wang, R; Sukenick, G; Salmon, J; Warren, JD; Ma, X; Barrat, FJ; Nathan, CF; Lin, G Structure-Activity Relationships of Noncovalent Immunoproteasome ?5i-Selective Dipeptides. J Med Chem63:13103-13123 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-8 |
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| Name: | Proteasome subunit beta type-8 |
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| Synonyms: | 26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30357.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1446797 |
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| Residue: | 276 |
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| Sequence: | MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
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| BDBM50554369 |
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| n/a |
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| Name | BDBM50554369 |
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| Synonyms: | CHEMBL4745016 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29F3N4O5 |
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| Mol. Mass. | 510.5061 |
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| SMILES | C[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)C(F)(F)F)C(=O)NCc1cccc2ccccc12 |r| |
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| Structure | 
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