Found 124 hits with Last Name = 'warren' and Initial = 'jd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010993
(CHEMBL3265177)Show InChI InChI=1S/C8H4N2O4S/c11-8-14-7(9-15-8)5-2-1-3-6(4-5)10(12)13/h1-4H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010988
(CHEMBL3259882)Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(cc1)-c1nsc(=O)o1 |r| Show InChI InChI=1S/C19H17N3O4S/c1-12(23)20-16(11-13-5-3-2-4-6-13)17(24)21-15-9-7-14(8-10-15)18-22-27-19(25)26-18/h2-10,16H,11H2,1H3,(H,20,23)(H,21,24)/t16-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010986
(CHEMBL2336253)Show InChI InChI=1S/C7H4N2O4S2/c1-3-4(9(11)12)2-5(14-3)6-8-15-7(10)13-6/h2H,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 760 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010997
(CHEMBL3265182)Show InChI InChI=1S/C13H14N2O4S/c1-13(2,3)19-11(16)14-9-6-4-8(5-7-9)10-15-20-12(17)18-10/h4-7H,1-3H3,(H,14,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010995
(CHEMBL3265180)Show InChI InChI=1S/C10H6N2O2S/c13-10-14-9(12-15-10)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50011003
(CHEMBL3259879)Show InChI InChI=1S/C13H14N2O3S/c16-13-18-12(14-19-13)11-3-1-2-10(8-11)9-15-4-6-17-7-5-15/h1-3,8H,4-7,9H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010999
(CHEMBL3259876)Show InChI InChI=1S/C14H9NO2S/c16-14-17-13(15-18-14)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50011001
(CHEMBL3259877)Show InChI InChI=1S/C8H5NO5S/c10-4-1-3(2-5(11)6(4)12)7-9-15-8(13)14-7/h1-2,10-12H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010996
(CHEMBL3265181)Show InChI InChI=1S/C9H4F3NO2S/c10-9(11,12)6-4-2-1-3-5(6)7-13-16-8(14)15-7/h1-4H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010994
(CHEMBL3265178)Show InChI InChI=1S/C7H4N2O2S/c10-7-11-6(9-12-7)5-3-1-2-4-8-5/h1-4H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010987
(CHEMBL3259880)Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)Nc1ccc(cc1)-c1nsc(=O)o1 |r| Show InChI InChI=1S/C19H17N3O4S/c1-12(23)20-16(11-13-5-3-2-4-6-13)17(24)21-15-9-7-14(8-10-15)18-22-27-19(25)26-18/h2-10,16H,11H2,1H3,(H,20,23)(H,21,24)/t16-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50010991
(CHEMBL3259884)Show InChI InChI=1S/C8H4N4O2S/c9-12-10-6-3-1-5(2-4-6)7-11-15-8(13)14-7/h1-4H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50011002
(CHEMBL3259878)Show InChI InChI=1S/C14H9NO2S/c16-14-17-13(15-18-14)12-8-4-7-11(9-12)10-5-2-1-3-6-10/h1-9H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50332796
(5-phenyl-1,3,4-oxathiazol-2-one | CHEMBL1632533)Show InChI InChI=1S/C8H5NO2S/c10-8-11-7(9-12-8)6-4-2-1-3-5-6/h1-5H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medical College
Curated by ChEMBL
| Assay Description Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min... |
ACS Med Chem Lett 5: 405-10 (2014)
Article DOI: 10.1021/ml400531d BindingDB Entry DOI: 10.7270/Q2PZ5BCF |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554394
(CHEMBL4784875)Show SMILES C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554392
(CHEMBL4751044)Show SMILES COC[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)c1cc(C)on1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554397
(CHEMBL4741140)Show SMILES COC[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554389
(CHEMBL4796570)Show SMILES C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)c1cc(C)on1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554385
(CHEMBL4764897)Show SMILES C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554386
(CHEMBL4758484)Show SMILES C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554384
(CHEMBL4784015)Show SMILES COC[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554395
(CHEMBL4763116)Show SMILES C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554358
(CHEMBL4754892)Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554357
(CHEMBL4516988)Show SMILES CC(C)(C)ONC(=O)C[C@H](NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554388
(CHEMBL4759896)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NC(=O)C(=O)c1c[nH]c2ccccc12)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554359
(CHEMBL4758527)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554383
(CHEMBL4782251)Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554393
(CHEMBL4764263)Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NC(=O)c1cc(C)on1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554391
(CHEMBL4776824)Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NC(=O)c1cc(C)on1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554365
(CHEMBL4764833)Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc(OC)c1 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554388
(CHEMBL4759896)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NC(=O)C(=O)c1c[nH]c2ccccc12)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity in human KARPAS-1106P cells incubated for 2 hrs by proteasome-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554396
(CHEMBL4764229)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554390
(CHEMBL4784421)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NC(=O)c1cc(C)on1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554373
(CHEMBL4764343)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)c1cc(C)on1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554376
(CHEMBL4746069)Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554367
(CHEMBL4762452)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)CCCc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554395
(CHEMBL4763116)Show SMILES C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity in human KARPAS-1106P cells incubated for 2 hrs by proteasome-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554368
(CHEMBL4795707)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)Cc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554397
(CHEMBL4741140)Show SMILES COC[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity in human KARPAS-1106P cells incubated for 2 hrs by proteasome-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554362
(CHEMBL4747215)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2[nH]ccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554386
(CHEMBL4758484)Show SMILES C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity in human KARPAS-1106P cells incubated for 2 hrs by proteasome-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554382
(CHEMBL4779742)Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)N1CCCCC1)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554387
(CHEMBL4782050)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554389
(CHEMBL4796570)Show SMILES C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)c1cc(C)on1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity in human KARPAS-1106P cells incubated for 2 hrs by proteasome-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-5
(Homo sapiens (Human)) | BDBM50554384
(CHEMBL4784015)Show SMILES COC[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human constitutive 20S proteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554398
(CHEMBL4799140)Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)NCc1ccc(F)c2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-5
(Homo sapiens (Human)) | BDBM50554388
(CHEMBL4759896)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NC(C)(C)C)NC(=O)C(=O)c1c[nH]c2ccccc12)C(=O)NCc1cccc2ccccc12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human constitutive 20S proteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554363
(CHEMBL4763630)Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc2cccnc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50554369
(CHEMBL4745016)Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)C(F)(F)F)C(=O)NCc1cccc2ccccc12 |r| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-5
(Homo sapiens (Human)) | BDBM50554365
(CHEMBL4764833)Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NOC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1cccc(OC)c1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human constitutive 20S proteasome beta 5 chymotrypsin-like activity |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01520 BindingDB Entry DOI: 10.7270/Q22R3WB6 |
More data for this Ligand-Target Pair | |