| Reaction Details |
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 | Report a problem with these data |
| Target | Polycomb protein EED |
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| Ligand | BDBM50575286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2124802 (CHEMBL4834035) |
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| IC50 | 21±n/a nM |
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| Citation |  Bagal, SK; Gregson, C; O' Donovan, DH; Pike, KG; Bloecher, A; Barton, P; Borodovsky, A; Code, E; Fillery, SM; Hsu, JH; Kawatkar, SP; Li, C; Longmire, D; Nai, Y; Nash, SC; Pike, A; Robinson, J; Read, JA; Rawlins, PB; Shen, M; Tang, J; Wang, P; Woods, H; Williamson, B Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase. J Med Chem64:17146-17183 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polycomb protein EED |
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| Name: | Polycomb protein EED |
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| Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
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| Type: | Protein |
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| Mol. Mass.: | 50201.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75530 |
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| Residue: | 441 |
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| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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| BDBM50575286 |
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| n/a |
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| Name | BDBM50575286 |
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| Synonyms: | CHEMBL4862641 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18FN5O2 |
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| Mol. Mass. | 403.409 |
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| SMILES | Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)c2cn[nH]c(=O)c12 |
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| Structure | 
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