| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase-1 |
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| Ligand | BDBM50577458 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2135941 (CHEMBL4845551) |
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| IC50 | 16±n/a nM |
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| Citation |  Li, D; Zhang, H; Lyons, TW; Lu, M; Achab, A; Pu, Q; Childers, M; Mitcheltree, MJ; Wang, J; Martinot, TA; McMinn, SE; Sloman, DL; Palani, A; Beard, A; Nogle, L; Gathiaka, S; Saurí, J; Kim, HY; Adpressa, D; Spacciapoli, P; Miller, JR; Palte, RL; Lesburg, CA; Cumming, J; Fischer, C Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors. ACS Med Chem Lett12:1678-1688 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arginase-1 |
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| Name: | Arginase-1 |
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| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34737.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_978893 |
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| Residue: | 322 |
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| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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| BDBM50577458 |
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| n/a |
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| Name | BDBM50577458 |
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| Synonyms: | CHEMBL4858437 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H16BNO4 |
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| Mol. Mass. | 201.028 |
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| SMILES | OB(O)CCC[C@@H]1CCN[C@@H]1C(O)=O |r| |
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| Structure | 
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