Reaction Details |
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Target | Proprotein convertase subtilisin/kexin type 9 |
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Ligand | BDBM50581538 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2151332 (CHEMBL5035794) |
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Ki | 4.7±n/a nM |
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Citation | Tucker, TJ; Embrey, MW; Alleyne, C; Amin, RP; Bass, A; Bhatt, B; Bianchi, E; Branca, D; Bueters, T; Buist, N; Ha, SN; Hafey, M; He, H; Higgins, J; Johns, DG; Kerekes, AD; Koeplinger, KA; Kuethe, JT; Li, N; Murphy, B; Orth, P; Salowe, S; Shahripour, A; Tracy, R; Wang, W; Wu, C; Xiong, Y; Zokian, HJ; Wood, HB; Walji, A A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors. J Med Chem64:16770-16800 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proprotein convertase subtilisin/kexin type 9 |
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Name: | Proprotein convertase subtilisin/kexin type 9 |
Synonyms: | NARC-1 | NARC1 | Neural apoptosis-regulated convertase 1 | PC9 | PCSK9 | PCSK9_HUMAN | Proprotein convertase 9 | Proprotein convertase subtilisin/kexin type 9 | Proprotein convertase subtilisin/kexin type 9 (PCSK9) | Subtilisin/kexin type 9 | Subtilisin/kexin-like protease PC9 |
Type: | Enzyme |
Mol. Mass.: | 74286.93 |
Organism: | Homo sapiens (Human) |
Description: | Q8NBP7 |
Residue: | 692 |
Sequence: | MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP
GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV
EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG
VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA
CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD
LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA
KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD
EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP
PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC
CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD
VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
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BDBM50581538 |
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n/a |
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Name | BDBM50581538 |
Synonyms: | CHEMBL5081995 |
Type | Small organic molecule |
Emp. Form. | C68H83FN10O12S2 |
Mol. Mass. | 1315.575 |
SMILES | COc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3[C@@H]4CCN3C(=O)[C@H](Cc3c[nH]c5ccc(F)cc35)NC(=O)[C@H](Cc3cccc(C\C=C/CO4)c3)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc3cccc(CSCCNC(=O)[C@]4(C)CCCN4C2=O)c3)[C@@H](C)O)cc1 |r,c:48| |
Structure |
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