| Reaction Details |
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 | Report a problem with these data |
| Target | Galectin-3 |
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| Ligand | BDBM541726 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2213339 (CHEMBL5126288) |
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| IC50 | 32±n/a nM |
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| Citation |  Liu, C; Jalagam, PR; Feng, J; Wang, W; Raja, T; Sura, MR; Manepalli, RKVLP; Aliphedi, BR; Medavarapu, S; Nair, SK; Muthalagu, V; Natesan, R; Gupta, A; Beno, B; Panda, M; Ghosh, K; Shukla, JK; Sale, H; Haldar, P; Kalidindi, N; Shah, D; Patel, D; Mathur, A; Ellsworth, BA; Cheng, D; Regueiro-Ren, A Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3. J Med Chem65:11084-11099 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Galectin-3 |
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| Name: | Galectin-3 |
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| Synonyms: | LEG3_HUMAN | LGALS3 | MAC2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26156.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17931 |
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| Residue: | 250 |
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| Sequence: | MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPP
GAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNL
PLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNN
WGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDI
DLTSASYTMI
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| BDBM541726 |
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| n/a |
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| Name | BDBM541726 |
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| Synonyms: | US11267811, Example A56 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H23ClF4N6O4 |
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| Mol. Mass. | 618.967 |
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| SMILES | Cc1nc([C@@H]2O[C@H](CO)[C@H](O)[C@@H]([C@H]2O)n2cc(nn2)-c2cc(F)c3ccccc3c2)n(n1)-c1cc(Cl)ccc1C(F)(F)F |r| |
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| Structure | 
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