| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase 1 |
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| Ligand | BDBM50185589 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_371820 (CHEMBL865551) |
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| IC50 | 37±n/a nM |
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| Citation |  Watkins, WJ; Chen, JM; Cho, A; Chong, L; Collins, N; Fardis, M; Huang, W; Hung, M; Kirschberg, T; Lee, WA; Liu, X; Thomas, W; Xu, J; Zeynalzadegan, A; Zhang, J Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH. Bioorg Med Chem Lett16:3479-83 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase 1 |
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| Name: | Inosine-5'-monophosphate dehydrogenase 1 |
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| Synonyms: | IMDH1_HUMAN | IMP dehydrogenase 1 | IMPD 1 | IMPD1 | IMPDH-I | IMPDH1 | Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55407.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant IMPDH1 expressed in E. coli. |
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| Residue: | 514 |
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| Sequence: | MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV
LSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMT
PRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDS
QKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR
SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
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| BDBM50185589 |
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| n/a |
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| Name | BDBM50185589 |
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| Synonyms: | (E)-2-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enylamino)ethylphosphonic acid | CHEMBL208921 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H26NO6P |
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| Mol. Mass. | 383.3759 |
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| SMILES | CCc1c(C)c2COC(=O)c2c(O)c1CC=C(C)CNCCP(O)(O)=O |w:15.16| |
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| Structure | 
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