Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Ceramide glucosyltransferase |
---|
Ligand | BDBM50406125 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2266215 |
---|
IC50 | >28000±n/a nM |
---|
Citation | Roecker, AJ; Schirripa, KM; Loughran, HM; Tong, L; Liang, T; Fillgrove, KL; Kuo, Y; Bleasby, K; Collier, H; Altman, MD; Ford, MC; Drolet, RE; Cosden, M; Jinn, S; Hatcher, NG; Yao, L; Kandebo, M; Vardigan, JD; Flick, RB; Liu, X; Minnick, C; Price, LA; Watt, ML; Lemaire, W; Burlein, C; Adam, GC; Austin, LA; Marcus, JN; Smith, SM; Fraley, ME Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease. ACS Med Chem Lett14:146-155 (2023) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ceramide glucosyltransferase |
---|
Name: | Ceramide glucosyltransferase |
Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
Type: | PROTEIN |
Mol. Mass.: | 44859.25 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1435474 |
Residue: | 394 |
Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
|
|
|
BDBM50406125 |
---|
n/a |
---|
Name | BDBM50406125 |
Synonyms: | CHEMBL5291482 |
Type | Small organic molecule |
Emp. Form. | C22H25N5O3 |
Mol. Mass. | 407.4656 |
SMILES | COc1ccc(cc1)-n1nc(C(=O)N2CC(C2)c2cnc(C)n2C)c2COCCc12 |
Structure |
|