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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A | ||
| Ligand | BDBM50406131 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2266221 | ||
| IC50 | 338±n/a nM | ||
| Citation |  Roecker, AJ; Schirripa, KM; Loughran, HM; Tong, L; Liang, T; Fillgrove, KL; Kuo, Y; Bleasby, K; Collier, H; Altman, MD; Ford, MC; Drolet, RE; Cosden, M; Jinn, S; Hatcher, NG; Yao, L; Kandebo, M; Vardigan, JD; Flick, RB; Liu, X; Minnick, C; Price, LA; Watt, ML; Lemaire, W; Burlein, C; Adam, GC; Austin, LA; Marcus, JN; Smith, SM; Fraley, ME Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease. ACS Med Chem Lett14:146-155 (2023) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 55283.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P46098 | ||
| Residue: | 478 | ||
| Sequence: |
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| BDBM50406131 | |||
| n/a | |||
| Name | BDBM50406131 | ||
| Synonyms: | CHEMBL5278405 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H26N4O3 | ||
| Mol. Mass. | 382.4561 | ||
| SMILES | COc1ccc(cc1)-c1nn(C(=O)N2CCN3CCC2CC3)c2COCCc12 |(2.68,-6.33,;1.19,-5.94,;.8,-4.45,;1.82,-3.32,;1.31,-1.83,;-.18,-1.52,;-1.21,-2.65,;-.74,-4.14,;-.64,-.08,;.28,1.2,;-.64,2.43,;-.18,3.87,;-1.26,5,;1.31,4.23,;2.28,3,;3.82,3,;4.8,4.18,;3.47,3.82,;2.23,4.43,;1.72,5.72,;3.11,6.33,;4.49,5.67,;-2.13,1.97,;-3.47,2.74,;-4.8,1.97,;-4.8,.43,;-3.47,-.34,;-2.13,.43,)| | ||
| Structure | 
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