| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50216939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_456815 (CHEMBL924198) |
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| EC50 | 2718±n/a nM |
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| Citation |  Wickens, P; Zhang, C; Ma, X; Zhao, Q; Amatruda, J; Bullock, W; Burns, M; Cantin, LD; Chuang, CY; Claus, T; Dai, M; Dela Cruz, F; Dickson, D; Ehrgott, FJ; Fan, D; Heald, S; Hentemann, M; Iwuagwu, CI; Johnson, JS; Kumarasinghe, E; Ladner, D; Lavoie, R; Liang, S; Livingston, JN; Lowe, D; Magnuson, S; Mannelly, G; Mugge, I; Ogutu, H; Pleasic-Williams, S; Schoenleber, RW; Shapiro, J; Shelekhin, T; Sweet, L; Town, C; Tsutsumi, M Indanylacetic acids as PPAR-delta activator insulin sensitizers. Bioorg Med Chem Lett17:4369-73 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50216939 |
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| n/a |
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| Name | BDBM50216939 |
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| Synonyms: | CHEMBL246207 | {(S)-5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-indan-1-yl}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27NO4 |
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| Mol. Mass. | 453.529 |
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| SMILES | Cc1oc(nc1CCOc1ccc2[C@H](CC(O)=O)CCc2c1)-c1ccc(cc1)-c1ccccc1 |
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| Structure | 
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