| Reaction Details |
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 | Report a problem with these data |
| Target | Glucagon receptor |
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| Ligand | BDBM50245060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_513211 (CHEMBL977341) |
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| IC50 | 6±n/a nM |
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| Citation |  Kodra, JT; Jørgensen, AS; Andersen, B; Behrens, C; Brand, CL; Christensen, IT; Guldbrandt, M; Jeppesen, CB; Knudsen, LB; Madsen, P; Nishimura, E; Sams, C; Sidelmann, UG; Pedersen, RA; Lynn, FC; Lau, J Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. J Med Chem51:5387-96 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucagon receptor |
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| Name: | Glucagon receptor |
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| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54026.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47871 |
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| Residue: | 477 |
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| Sequence: | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
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| BDBM50245060 |
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| n/a |
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| Name | BDBM50245060 |
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| Synonyms: | (R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(4-trifluoromethylsulfanylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid | CHEMBL453457 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H32F3N3O5S |
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| Mol. Mass. | 615.663 |
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| SMILES | O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(SC(F)(F)F)cc2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| |
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| Structure | 
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