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Compile Data Set for Download or QSAR

Found 334 hits with Last Name = 'brand' and Initial = 'cl'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon receptor


(Rattus norvegicus)		BDBM50122102
PNG
(3-Cyano-4-hydroxy-benzoic acid [1-(2,3,5,6-tetrame...)
Show SMILES Cc1cc(C)c(C)c(Cn2ccc3c(\C=N\NC(=O)c4ccc(O)c(c4)C#N)cccc23)c1C
Show InChI InChI=1S/C28H26N4O2/c1-17-12-18(2)20(4)25(19(17)3)16-32-11-10-24-22(6-5-7-26(24)32)15-30-31-28(34)21-8-9-27(33)23(13-21)14-29/h5-13,15,33H,16H2,1-4H3,(H,31,34)/b30-15+
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n/an/a 0.430n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards rat glucagon receptor

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50110054
PNG
(3-Cyano-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(c2)C#N)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C27H27N3O5/c1-17(2)20-7-5-18(6-8-20)16-35-26-24(33-3)11-19(12-25(26)34-4)15-29-30-27(32)21-9-10-23(31)22(13-21)14-28/h5-13,15,17,31H,16H2,1-4H3,(H,30,32)/b29-15+
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n/an/a 1n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro for its inhibitory activity against rat glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122102
PNG
(3-Cyano-4-hydroxy-benzoic acid [1-(2,3,5,6-tetrame...)
Show SMILES Cc1cc(C)c(C)c(Cn2ccc3c(\C=N\NC(=O)c4ccc(O)c(c4)C#N)cccc23)c1C
Show InChI InChI=1S/C28H26N4O2/c1-17-12-18(2)20(4)25(19(17)3)16-32-11-10-24-22(6-5-7-26(24)32)15-30-31-28(34)21-8-9-27(33)23(13-21)14-29/h5-13,15,33H,16H2,1-4H3,(H,31,34)/b30-15+
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122159
PNG
(CHEMBL152477 | Cyclopentanecarboxylic acid {4-[(3-...)
Show SMILES Oc1ccc(cc1C#N)C(=O)NN=Cc1ccc(N(C(=O)C2CCCC2)C(=O)C2CCCC2)c2ccccc12 |w:12.12|
Show InChI InChI=1S/C31H30N4O4/c32-18-24-17-22(14-16-28(24)36)29(37)34-33-19-23-13-15-27(26-12-6-5-11-25(23)26)35(30(38)20-7-1-2-8-20)31(39)21-9-3-4-10-21/h5-6,11-17,19-21,36H,1-4,7-10H2,(H,34,37)
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122153
PNG
(CHEMBL156724 | Cyclopentanecarboxylic acid {4-[(3-...)
Show SMILES Oc1ccc(cc1Cl)C(=O)NN=Cc1ccc(N(C(=O)C2CCCC2)C(=O)C2CCCC2)c2ccccc12 |w:11.11|
Show InChI InChI=1S/C30H30ClN3O4/c31-25-17-21(14-16-27(25)35)28(36)33-32-18-22-13-15-26(24-12-6-5-11-23(22)24)34(29(37)19-7-1-2-8-19)30(38)20-9-3-4-10-20/h5-6,11-20,35H,1-4,7-10H2,(H,33,36)
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50244455
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichl...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:31|
Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50245098
PNG
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3,5-dichloroph...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r|
Show InChI InChI=1S/C30H31Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h6-16,20,27,36H,1-5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110074
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl...)
Show SMILES CC(C)c1ccc(COc2ccc(\C=N\NC(=O)c3ccc(O)c(Cl)c3)c3ccccc23)cc1
Show InChI InChI=1S/C28H25ClN2O3/c1-18(2)20-9-7-19(8-10-20)17-34-27-14-12-22(23-5-3-4-6-24(23)27)16-30-31-28(33)21-11-13-26(32)25(29)15-21/h3-16,18,32H,17H2,1-2H3,(H,31,33)/b30-16+
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122116
PNG
(3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(4-chloro...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(CC(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc12
Show InChI InChI=1S/C31H28Cl2N4O3/c32-25-10-5-21(6-11-25)20-36-13-15-37(16-14-36)30(39)18-22-7-8-24(27-4-2-1-3-26(22)27)19-34-35-31(40)23-9-12-29(38)28(33)17-23/h1-12,17,19,38H,13-16,18,20H2,(H,35,40)/b34-19+
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n/an/a 4.60n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122160
PNG
(3-Cyano-4-hydroxy-benzoic acid {4-[4-(4-chloro-ben...)
Show SMILES Oc1ccc(cc1C#N)C(=O)N\N=C\c1ccc(C(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc12
Show InChI InChI=1S/C31H26ClN5O3/c32-25-9-5-21(6-10-25)20-36-13-15-37(16-14-36)31(40)28-11-7-23(26-3-1-2-4-27(26)28)19-34-35-30(39)22-8-12-29(38)24(17-22)18-33/h1-12,17,19,38H,13-16,20H2,(H,35,39)/b34-19+
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50245102
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methane...)
Show SMILES CS(=O)(=O)c1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2=CCCCC2)ccc1OC(F)(F)F |r,t:35|
Show InChI InChI=1S/C32H32F3N3O8S/c1-47(44,45)28-17-24(13-16-27(28)46-32(33,34)35)37-31(43)38(25-14-11-22(12-15-25)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-26(39)30(41)42/h5,7-17,26,39H,2-4,6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t26-/m1/s1
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122135
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-(2,3,5,6-tetram...)
Show SMILES Cc1cc(C)c(C)c(Cn2ccc3c(\C=N\NC(=O)c4ccc(O)c(Cl)c4)cccc23)c1C
Show InChI InChI=1S/C27H26ClN3O2/c1-16-12-17(2)19(4)23(18(16)3)15-31-11-10-22-21(6-5-7-25(22)31)14-29-30-27(33)20-8-9-26(32)24(28)13-20/h5-14,32H,15H2,1-4H3,(H,30,33)/b29-14+
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122142
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-(2,4,6-trimethy...)
Show SMILES Cc1cc(C)c(Cn2ccc3c(\C=N\NC(=O)c4ccc(O)c(Cl)c4)cccc23)c(C)c1
Show InChI InChI=1S/C26H24ClN3O2/c1-16-11-17(2)22(18(3)12-16)15-30-10-9-21-20(5-4-6-24(21)30)14-28-29-26(32)19-7-8-25(31)23(27)13-19/h4-14,31H,15H2,1-3H3,(H,29,32)/b28-14+
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122152
PNG
(4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-n...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(C(=O)NCCc2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C27H21Cl2N3O3/c28-20-9-5-17(6-10-20)13-14-30-27(35)23-11-7-19(21-3-1-2-4-22(21)23)16-31-32-26(34)18-8-12-25(33)24(29)15-18/h1-12,15-16,33H,13-14H2,(H,30,35)(H,32,34)/b31-16+
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50245099
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(2,2,4,4-t...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc3OC(F)(F)OC(F)(F)c3c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:38|
Show InChI InChI=1S/C32H29F4N3O7/c33-31(34)25-16-23(12-15-27(25)45-32(35,36)46-31)38-30(44)39(24-13-10-21(11-14-24)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(41)37-17-26(40)29(42)43/h4,6-16,26,40H,1-3,5,17-18H2,(H,37,41)(H,38,44)(H,42,43)/t26-/m1/s1
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50245060
PNG
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(4-trifluoromet...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(SC(F)(F)F)cc2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r|
Show InChI InChI=1S/C31H32F3N3O5S/c32-31(33,34)43-26-16-12-24(13-17-26)36-30(42)37(25-14-10-22(11-15-25)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)28(39)35-18-27(38)29(40)41/h6-17,21,27,38H,1-5,18-19H2,(H,35,39)(H,36,42)(H,40,41)/t27-/m1/s1
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122158
PNG
(3-Cyano-4-hydroxy-benzoic acid (4-{2-[4-(4-bromo-p...)
Show SMILES Oc1ccc(cc1C#N)C(=O)N\N=C\c1ccc(OCC(=O)N2CCC(=CC2)c2ccc(Br)cc2)c2ccccc12 |c:26|
Show InChI InChI=1S/C32H25BrN4O4/c33-26-9-5-21(6-10-26)22-13-15-37(16-14-22)31(39)20-41-30-12-8-24(27-3-1-2-4-28(27)30)19-35-36-32(40)23-7-11-29(38)25(17-23)18-34/h1-13,17,19,38H,14-16,20H2,(H,36,40)/b35-19+
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122125
PNG
(CHEMBL421809 | N-Benzyl-2-{4-[(3-chloro-4-hydroxy-...)
Show SMILES CN(C)CCN(Cc1ccccc1)C(=O)Cc1ccc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C31H31ClN4O3/c1-35(2)16-17-36(21-22-8-4-3-5-9-22)30(38)19-23-12-13-25(27-11-7-6-10-26(23)27)20-33-34-31(39)24-14-15-29(37)28(32)18-24/h3-15,18,20,37H,16-17,19,21H2,1-2H3,(H,34,39)/b33-20+
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n/an/a 6.20n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50409681
PNG
(CHEMBL2112908)
Show SMILES Oc1ccc(cc1C#N)C(=O)N\N=C\c1cn(C(=O)CC2CCCC2)c2ccccc12
Show InChI InChI=1S/C24H22N4O3/c25-13-18-12-17(9-10-22(18)29)24(31)27-26-14-19-15-28(21-8-4-3-7-20(19)21)23(30)11-16-5-1-2-6-16/h3-4,7-10,12,14-16,29H,1-2,5-6,11H2,(H,27,31)/b26-14+
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n/an/a 6.40n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122124
PNG
(3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(4-bromo-...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(OCC(=O)N2CCC(=CC2)c2ccc(Br)cc2)c2ccccc12 |c:25|
Show InChI InChI=1S/C31H25BrClN3O4/c32-24-9-5-20(6-10-24)21-13-15-36(16-14-21)30(38)19-40-29-12-8-23(25-3-1-2-4-26(25)29)18-34-35-31(39)22-7-11-28(37)27(33)17-22/h1-13,17-18,37H,14-16,19H2,(H,35,39)/b34-18+
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n/an/a 6.60n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50409679
PNG
(CHEMBL2112906)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(CS(=O)(=O)Cc2ccc(OC(F)(F)F)cc2)c2ccccc12
Show InChI InChI=1S/C27H20ClF3N2O5S/c28-24-13-18(9-12-25(24)34)26(35)33-32-14-19-7-8-20(23-4-2-1-3-22(19)23)16-39(36,37)15-17-5-10-21(11-6-17)38-27(29,30)31/h1-14,34H,15-16H2,(H,33,35)/b32-14+
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n/an/a 6.90n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50244507
PNG
((R)-3-{4-[3-(3-Bromo-5-trifluoromethylphenyl)-1-(4...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Br)cc(c2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:34|
Show InChI InChI=1S/C31H29BrF3N3O5/c32-24-14-23(31(33,34)35)15-25(16-24)37-30(43)38(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(40)36-17-27(39)29(41)42/h4,6-16,27,39H,1-3,5,17-18H2,(H,36,40)(H,37,43)(H,41,42)/t27-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50409675
PNG
(CHEMBL2111262)
Show SMILES NC(=O)[C@@H](Cc1ccccc1)Nc1ccc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)c2ccccc12 |r|
Show InChI InChI=1S/C27H23ClN4O3/c28-22-15-18(11-13-25(22)33)27(35)32-30-16-19-10-12-23(21-9-5-4-8-20(19)21)31-24(26(29)34)14-17-6-2-1-3-7-17/h1-13,15-16,24,31,33H,14H2,(H2,29,34)(H,32,35)/b30-16+/t24-/m1/s1
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n/an/a 7.40n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122146
PNG
(3-Chloro-4-hydroxy-benzoic acid {4-[2-(2-ethyl-pip...)
Show SMILES CCC1CCCCN1C(=O)Cc1ccc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C27H28ClN3O3/c1-2-21-7-5-6-14-31(21)26(33)16-18-10-11-20(23-9-4-3-8-22(18)23)17-29-30-27(34)19-12-13-25(32)24(28)15-19/h3-4,8-13,15,17,21,32H,2,5-7,14,16H2,1H3,(H,30,34)/b29-17+
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n/an/a 7.40n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122155
PNG
(3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(2-fluoro...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(CC(=O)N2CCN(CC2)c2ccccc2F)c2ccccc12
Show InChI InChI=1S/C30H26ClFN4O3/c31-25-17-21(11-12-28(25)37)30(39)34-33-19-22-10-9-20(23-5-1-2-6-24(22)23)18-29(38)36-15-13-35(14-16-36)27-8-4-3-7-26(27)32/h1-12,17,19,37H,13-16,18H2,(H,34,39)/b33-19+
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n/an/a 7.90n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50244506
PNG
((R)-3-{4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cccc(Br)c2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r|
Show InChI InChI=1S/C30H32BrN3O5/c31-24-7-4-8-25(17-24)33-30(39)34(26-15-13-22(14-16-26)21-5-2-1-3-6-21)19-20-9-11-23(12-10-20)28(36)32-18-27(35)29(37)38/h4,7-17,21,27,35H,1-3,5-6,18-19H2,(H,32,36)(H,33,39)(H,37,38)/t27-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50244457
PNG
((R)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NC[C@@H](O)C(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,wU:4.3,22.24,wD:7.10,(4.8,4.42,;4.81,2.87,;6.35,2.88,;3.27,2.87,;4.8,1.33,;6.14,.56,;6.13,-.98,;4.8,-1.74,;3.46,-.98,;3.47,.56,;4.8,-3.28,;3.47,-4.05,;2.13,-3.29,;.79,-4.06,;-.54,-3.29,;-.54,-1.74,;.79,-.97,;2.12,-1.74,;-1.87,-.97,;-1.87,.57,;-3.21,-1.74,;-4.54,-.97,;-5.87,-1.74,;-5.87,-3.28,;-7.21,-.97,;-7.21,.57,;-8.54,-1.74,;6.13,-4.05,;6.13,-5.59,;7.46,-3.28,;8.8,-4.05,;10.12,-3.27,;11.45,-4.03,;11.46,-5.58,;10.13,-6.35,;8.79,-5.59,;10.13,-7.89,;10.12,-9.43,;11.67,-7.9,;8.59,-7.9,;12.78,-3.26,;14.11,-2.47,;13.56,-4.58,;12,-1.93,)|
Show InChI InChI=1S/C30H35F6N3O5/c1-28(2,3)19-8-10-23(11-9-19)39(16-17-4-6-18(7-5-17)25(41)37-15-24(40)26(42)43)27(44)38-22-13-20(29(31,32)33)12-21(14-22)30(34,35)36/h4-7,12-14,19,23-24,40H,8-11,15-16H2,1-3H3,(H,37,41)(H,38,44)(H,42,43)/t19-,23-,24-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122109
PNG
(3-Chloro-4-hydroxy-benzoic acid {4-[2-(2-methyl-pi...)
Show SMILES CC1CCCCN1C(=O)Cc1ccc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C26H26ClN3O3/c1-17-6-4-5-13-30(17)25(32)15-18-9-10-20(22-8-3-2-7-21(18)22)16-28-29-26(33)19-11-12-24(31)23(27)14-19/h2-3,7-12,14,16-17,31H,4-6,13,15H2,1H3,(H,29,33)/b28-16+
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n/an/a 8.30n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122117
PNG
(3-Chloro-4-hydroxy-benzoic acid [4-(4-chloro-benzy...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(NCc2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C25H19Cl2N3O2/c26-19-9-5-16(6-10-19)14-28-23-11-7-18(20-3-1-2-4-21(20)23)15-29-30-25(32)17-8-12-24(31)22(27)13-17/h1-13,15,28,31H,14H2,(H,30,32)/b29-15+
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n/an/a 8.30n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50245101
PNG
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methylthio)p...)
Show SMILES CSc1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)c1 |r|
Show InChI InChI=1S/C31H35N3O5S/c1-40-27-9-5-8-25(18-27)33-31(39)34(26-16-14-23(15-17-26)22-6-3-2-4-7-22)20-21-10-12-24(13-11-21)29(36)32-19-28(35)30(37)38/h5,8-18,22,28,35H,2-4,6-7,19-20H2,1H3,(H,32,36)(H,33,39)(H,37,38)/t28-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50244509
PNG
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methoxy-5-tr...)
Show SMILES COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C32H34F3N3O6/c1-44-27-16-24(32(33,34)35)15-25(17-27)37-31(43)38(26-13-11-22(12-14-26)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-28(39)30(41)42/h7-17,21,28,39H,2-6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t28-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50245061
PNG
((R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r|
Show InChI InChI=1S/C32H31F3N4O5/c33-32(34,35)27-16-25(13-10-24(27)17-36)38-31(44)39(26-14-11-22(12-15-26)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(41)37-18-28(40)30(42)43/h6-16,21,28,40H,1-5,18-19H2,(H,37,41)(H,38,44)(H,42,43)/t28-/m1/s1
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122145
PNG
(3-Chloro-4-hydroxy-benzoic acid {4-[2-(4-benzyl-pi...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(CC(=O)N2CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C31H29ClN4O3/c32-28-18-24(12-13-29(28)37)31(39)34-33-20-25-11-10-23(26-8-4-5-9-27(25)26)19-30(38)36-16-14-35(15-17-36)21-22-6-2-1-3-7-22/h1-13,18,20,37H,14-17,19,21H2,(H,34,39)/b33-20+
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n/an/a 9.20n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50245057
PNG
((R)-trans-3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(3-m...)
Show SMILES Cc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)cc(c1)C(F)(F)F |r,wU:27.31,19.20,wD:24.24,(9.34,-6,;9.33,-4.46,;8,-3.69,;8.01,-2.15,;6.67,-1.38,;5.34,-2.15,;5.34,-3.69,;4,-1.38,;2.67,-2.16,;1.34,-1.39,;-0,-2.16,;-1.33,-1.39,;-1.33,.16,;-0,.93,;1.33,.16,;-2.67,.93,;-2.67,2.47,;-4,.15,;-5.33,.92,;-6.67,.15,;-6.67,-1.39,;-8,.92,;-8,2.46,;-9.34,.15,;4,.16,;5.34,.92,;5.34,2.46,;4.01,3.23,;2.67,2.46,;2.67,.92,;4.01,4.77,;4.01,6.32,;5.55,4.77,;2.47,4.76,;9.33,-1.38,;10.66,-2.14,;10.67,-3.68,;11.99,-1.36,;13.32,-.58,;12.77,-2.69,;11.21,-.03,)|
Show InChI InChI=1S/C30H38F3N3O5/c1-18-13-22(30(31,32)33)15-23(14-18)35-28(41)36(24-11-9-21(10-12-24)29(2,3)4)17-19-5-7-20(8-6-19)26(38)34-16-25(37)27(39)40/h5-8,13-15,21,24-25,37H,9-12,16-17H2,1-4H3,(H,34,38)(H,35,41)(H,39,40)/t21-,24-,25-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122129
PNG
(CHEMBL153879 | N-Benzyl-2-{4-[(3-cyano-4-hydroxy-b...)
Show SMILES CN(C)CCN(Cc1ccccc1)C(=O)Cc1ccc(\C=N\NC(=O)c2ccc(O)c(c2)C#N)c2ccccc12
Show InChI InChI=1S/C32H31N5O3/c1-36(2)16-17-37(22-23-8-4-3-5-9-23)31(39)19-24-12-13-26(29-11-7-6-10-28(24)29)21-34-35-32(40)25-14-15-30(38)27(18-25)20-33/h3-15,18,21,38H,16-17,19,22H2,1-2H3,(H,35,40)/b34-21+
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n/an/a 10.4n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122150
PNG
(3-Chloro-4-hydroxy-benzoic acid {4-[4-(4-chloro-be...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(C(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc12
Show InChI InChI=1S/C30H26Cl2N4O3/c31-23-9-5-20(6-10-23)19-35-13-15-36(16-14-35)30(39)26-11-7-22(24-3-1-2-4-25(24)26)18-33-34-29(38)21-8-12-28(37)27(32)17-21/h1-12,17-18,37H,13-16,19H2,(H,34,38)/b33-18+
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n/an/a 11.3n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122120
PNG
(3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(4-bromo-...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(OCC(=O)N2CCC(O)(CC2)c2ccc(Br)cc2)c2ccccc12
Show InChI InChI=1S/C31H27BrClN3O5/c32-23-9-7-22(8-10-23)31(40)13-15-36(16-14-31)29(38)19-41-28-12-6-21(24-3-1-2-4-25(24)28)18-34-35-30(39)20-5-11-27(37)26(33)17-20/h1-12,17-18,37,40H,13-16,19H2,(H,35,39)/b34-18+
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n/an/a 11.4n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122151
PNG
(3-Cyano-4-hydroxy-benzoic acid {4-[2-(2-methyl-pip...)
Show SMILES CC1CCCCN1C(=O)Cc1ccc(\C=N\NC(=O)c2ccc(O)c(c2)C#N)c2ccccc12
Show InChI InChI=1S/C27H26N4O3/c1-18-6-4-5-13-31(18)26(33)15-19-9-10-21(24-8-3-2-7-23(19)24)17-29-30-27(34)20-11-12-25(32)22(14-20)16-28/h2-3,7-12,14,17-18,32H,4-6,13,15H2,1H3,(H,30,34)/b29-17+
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n/an/a 11.6n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50202031
PNG
(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)
Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1 |t:33|
Show InChI InChI=1S/C30H29Cl2N3O4/c31-24-16-25(32)18-26(17-24)34-30(39)35(27-12-10-22(11-13-27)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(38)33-15-14-28(36)37/h4,6-13,16-18H,1-3,5,14-15,19H2,(H,33,38)(H,34,39)(H,36,37)
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n/an/a 12n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens (Human))		BDBM50245060
PNG
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(4-trifluoromet...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(SC(F)(F)F)cc2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r|
Show InChI InChI=1S/C31H32F3N3O5S/c32-31(33,34)43-26-16-12-24(13-17-26)36-30(42)37(25-14-10-22(11-15-25)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)28(39)35-18-27(38)29(40)41/h6-17,21,27,38H,1-5,18-19H2,(H,35,39)(H,36,42)(H,40,41)/t27-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122148
PNG
(3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(4-fluoro...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(CC(=O)N2CCN(CC2)c2ccc(F)cc2)c2ccccc12
Show InChI InChI=1S/C30H26ClFN4O3/c31-27-17-21(7-12-28(27)37)30(39)34-33-19-22-6-5-20(25-3-1-2-4-26(22)25)18-29(38)36-15-13-35(14-16-36)24-10-8-23(32)9-11-24/h1-12,17,19,37H,13-16,18H2,(H,34,39)/b33-19+
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n/an/a 12.3n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50409684
PNG
(CHEMBL2111565)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1cccc2c(OCc3ccc(OC(F)(F)F)cc3)cccc12
Show InChI InChI=1S/C26H18ClF3N2O4/c27-22-13-17(9-12-23(22)33)25(34)32-31-14-18-3-1-5-21-20(18)4-2-6-24(21)35-15-16-7-10-19(11-8-16)36-26(28,29)30/h1-14,33H,15H2,(H,32,34)/b31-14+
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n/an/a 12.9n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50245100
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-fluoro-...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(F)cc(c2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:34|
Show InChI InChI=1S/C31H29F4N3O5/c32-24-14-23(31(33,34)35)15-25(16-24)37-30(43)38(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(40)36-17-27(39)29(41)42/h4,6-16,27,39H,1-3,5,17-18H2,(H,36,40)(H,37,43)(H,41,42)/t27-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122107
PNG
(3-Chloro-4-hydroxy-benzoic acid {4-[2-(3,4-dihydro...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(OCC(=O)N2CCc3ccccc3C2)c2ccccc12
Show InChI InChI=1S/C29H24ClN3O4/c30-25-15-20(9-11-26(25)34)29(36)32-31-16-21-10-12-27(24-8-4-3-7-23(21)24)37-18-28(35)33-14-13-19-5-1-2-6-22(19)17-33/h1-12,15-16,34H,13-14,17-18H2,(H,32,36)/b31-16+
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n/an/a 13.8n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50244508
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methoxy...)
Show SMILES COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2=CCCCC2)cc(c1)C(F)(F)F |r,t:33|
Show InChI InChI=1S/C32H32F3N3O6/c1-44-27-16-24(32(33,34)35)15-25(17-27)37-31(43)38(26-13-11-22(12-14-26)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-28(39)30(41)42/h5,7-17,28,39H,2-4,6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t28-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50244454
PNG
((R/S)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dic...)
Show SMILES OC(CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |t:31|
Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39)
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n/an/a 14n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50245059
PNG
((R)-3-{4-[3-(3-Chlorophenyl)-1-(4-cyclohex-1-enylp...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cccc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:30|
Show InChI InChI=1S/C30H30ClN3O5/c31-24-7-4-8-25(17-24)33-30(39)34(26-15-13-22(14-16-26)21-5-2-1-3-6-21)19-20-9-11-23(12-10-20)28(36)32-18-27(35)29(37)38/h4-5,7-17,27,35H,1-3,6,18-19H2,(H,32,36)(H,33,39)(H,37,38)/t27-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GluR expressed in BHK cells

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122164
PNG
(CHEMBL346694 | N-{4-[(3-Chloro-4-hydroxy-benzoyl)-...)
Show SMILES COc1cc(NC(=O)CSc2ccc(OC(F)(F)F)cc2)ccc1\C=N\NC(=O)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C24H19ClF3N3O5S/c1-35-21-11-16(30-22(33)13-37-18-7-5-17(6-8-18)36-24(26,27)28)4-2-15(21)12-29-31-23(34)14-3-9-20(32)19(25)10-14/h2-12,32H,13H2,1H3,(H,30,33)(H,31,34)/b29-12+
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n/an/a 14.5n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122130
PNG
(3-Chloro-4-hydroxy-benzoic acid {4-[2-(3,4-dichlor...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(OCCNCc2ccc(Cl)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C27H22Cl3N3O3/c28-22-8-5-17(13-23(22)29)15-31-11-12-36-26-10-7-19(20-3-1-2-4-21(20)26)16-32-33-27(35)18-6-9-25(34)24(30)14-18/h1-10,13-14,16,31,34H,11-12,15H2,(H,33,35)/b32-16+
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n/an/a 14.7n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50122098
PNG
(CHEMBL413964 | N-{4-[(3-Cyano-4-hydroxy-benzoyl)-h...)
Show SMILES COc1cc(NC(=O)CCc2ccc(cc2)C(F)(F)F)ccc1\C=N\NC(=O)c1ccc(O)c(c1)C#N
Show InChI InChI=1S/C26H21F3N4O4/c1-37-23-13-21(32-24(35)11-4-16-2-7-20(8-3-16)26(27,28)29)9-5-18(23)15-31-33-25(36)17-6-10-22(34)19(12-17)14-30/h2-3,5-10,12-13,15,34H,4,11H2,1H3,(H,32,35)(H,33,36)/b31-15+
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n/an/a 15.7n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
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