Found 302 hits with Last Name = 'behrens' and Initial = 'c' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Homo sapiens (Human)) | BDBM50244455
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichl...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:31| Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245098
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3,5-dichloroph...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| Show InChI InChI=1S/C30H31Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h6-16,20,27,36H,1-5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245102
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methane...)Show SMILES CS(=O)(=O)c1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2=CCCCC2)ccc1OC(F)(F)F |r,t:35| Show InChI InChI=1S/C32H32F3N3O8S/c1-47(44,45)28-17-24(13-16-27(28)46-32(33,34)35)37-31(43)38(25-14-11-22(12-15-25)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-26(39)30(41)42/h5,7-17,26,39H,2-4,6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t26-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245060
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(4-trifluoromet...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(SC(F)(F)F)cc2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| Show InChI InChI=1S/C31H32F3N3O5S/c32-31(33,34)43-26-16-12-24(13-17-26)36-30(42)37(25-14-10-22(11-15-25)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)28(39)35-18-27(38)29(40)41/h6-17,21,27,38H,1-5,18-19H2,(H,35,39)(H,36,42)(H,40,41)/t27-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245099
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(2,2,4,4-t...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc3OC(F)(F)OC(F)(F)c3c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:38| Show InChI InChI=1S/C32H29F4N3O7/c33-31(34)25-16-23(12-15-27(25)45-32(35,36)46-31)38-30(44)39(24-13-10-21(11-14-24)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(41)37-17-26(40)29(42)43/h4,6-16,26,40H,1-3,5,17-18H2,(H,37,41)(H,38,44)(H,42,43)/t26-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50244507
((R)-3-{4-[3-(3-Bromo-5-trifluoromethylphenyl)-1-(4...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Br)cc(c2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:34| Show InChI InChI=1S/C31H29BrF3N3O5/c32-24-14-23(31(33,34)35)15-25(16-24)37-30(43)38(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(40)36-17-27(39)29(41)42/h4,6-16,27,39H,1-3,5,17-18H2,(H,36,40)(H,37,43)(H,41,42)/t27-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50244506
((R)-3-{4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cccc(Br)c2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| Show InChI InChI=1S/C30H32BrN3O5/c31-24-7-4-8-25(17-24)33-30(39)34(26-15-13-22(14-16-26)21-5-2-1-3-6-21)19-20-9-11-23(12-10-20)28(36)32-18-27(35)29(37)38/h4,7-17,21,27,35H,1-3,5-6,18-19H2,(H,32,36)(H,33,39)(H,37,38)/t27-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50244457
((R)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NC[C@@H](O)C(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,wU:4.3,22.24,wD:7.10,(4.8,4.42,;4.81,2.87,;6.35,2.88,;3.27,2.87,;4.8,1.33,;6.14,.56,;6.13,-.98,;4.8,-1.74,;3.46,-.98,;3.47,.56,;4.8,-3.28,;3.47,-4.05,;2.13,-3.29,;.79,-4.06,;-.54,-3.29,;-.54,-1.74,;.79,-.97,;2.12,-1.74,;-1.87,-.97,;-1.87,.57,;-3.21,-1.74,;-4.54,-.97,;-5.87,-1.74,;-5.87,-3.28,;-7.21,-.97,;-7.21,.57,;-8.54,-1.74,;6.13,-4.05,;6.13,-5.59,;7.46,-3.28,;8.8,-4.05,;10.12,-3.27,;11.45,-4.03,;11.46,-5.58,;10.13,-6.35,;8.79,-5.59,;10.13,-7.89,;10.12,-9.43,;11.67,-7.9,;8.59,-7.9,;12.78,-3.26,;14.11,-2.47,;13.56,-4.58,;12,-1.93,)| Show InChI InChI=1S/C30H35F6N3O5/c1-28(2,3)19-8-10-23(11-9-19)39(16-17-4-6-18(7-5-17)25(41)37-15-24(40)26(42)43)27(44)38-22-13-20(29(31,32)33)12-21(14-22)30(34,35)36/h4-7,12-14,19,23-24,40H,8-11,15-16H2,1-3H3,(H,37,41)(H,38,44)(H,42,43)/t19-,23-,24-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245101
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methylthio)p...)Show SMILES CSc1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)c1 |r| Show InChI InChI=1S/C31H35N3O5S/c1-40-27-9-5-8-25(18-27)33-31(39)34(26-16-14-23(15-17-26)22-6-3-2-4-7-22)20-21-10-12-24(13-11-21)29(36)32-19-28(35)30(37)38/h5,8-18,22,28,35H,2-4,6-7,19-20H2,1H3,(H,32,36)(H,33,39)(H,37,38)/t28-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50244509
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methoxy-5-tr...)Show SMILES COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C32H34F3N3O6/c1-44-27-16-24(32(33,34)35)15-25(17-27)37-31(43)38(26-13-11-22(12-14-26)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-28(39)30(41)42/h7-17,21,28,39H,2-6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t28-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245061
((R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| Show InChI InChI=1S/C32H31F3N4O5/c33-32(34,35)27-16-25(13-10-24(27)17-36)38-31(44)39(26-14-11-22(12-15-26)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(41)37-18-28(40)30(42)43/h6-16,21,28,40H,1-5,18-19H2,(H,37,41)(H,38,44)(H,42,43)/t28-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245057
((R)-trans-3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(3-m...)Show SMILES Cc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)cc(c1)C(F)(F)F |r,wU:27.31,19.20,wD:24.24,(9.34,-6,;9.33,-4.46,;8,-3.69,;8.01,-2.15,;6.67,-1.38,;5.34,-2.15,;5.34,-3.69,;4,-1.38,;2.67,-2.16,;1.34,-1.39,;-0,-2.16,;-1.33,-1.39,;-1.33,.16,;-0,.93,;1.33,.16,;-2.67,.93,;-2.67,2.47,;-4,.15,;-5.33,.92,;-6.67,.15,;-6.67,-1.39,;-8,.92,;-8,2.46,;-9.34,.15,;4,.16,;5.34,.92,;5.34,2.46,;4.01,3.23,;2.67,2.46,;2.67,.92,;4.01,4.77,;4.01,6.32,;5.55,4.77,;2.47,4.76,;9.33,-1.38,;10.66,-2.14,;10.67,-3.68,;11.99,-1.36,;13.32,-.58,;12.77,-2.69,;11.21,-.03,)| Show InChI InChI=1S/C30H38F3N3O5/c1-18-13-22(30(31,32)33)15-23(14-18)35-28(41)36(24-11-9-21(10-12-24)29(2,3)4)17-19-5-7-20(8-6-19)26(38)34-16-25(37)27(39)40/h5-8,13-15,21,24-25,37H,9-12,16-17H2,1-4H3,(H,34,38)(H,35,41)(H,39,40)/t21-,24-,25-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202031
(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1 |t:33| Show InChI InChI=1S/C30H29Cl2N3O4/c31-24-16-25(32)18-26(17-24)34-30(39)35(27-12-10-22(11-13-27)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(38)33-15-14-28(36)37/h4,6-13,16-18H,1-3,5,14-15,19H2,(H,33,38)(H,34,39)(H,36,37) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245060
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(4-trifluoromet...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(SC(F)(F)F)cc2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| Show InChI InChI=1S/C31H32F3N3O5S/c32-31(33,34)43-26-16-12-24(13-17-26)36-30(42)37(25-14-10-22(11-15-25)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)28(39)35-18-27(38)29(40)41/h6-17,21,27,38H,1-5,18-19H2,(H,35,39)(H,36,42)(H,40,41)/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245100
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-fluoro-...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(F)cc(c2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:34| Show InChI InChI=1S/C31H29F4N3O5/c32-24-14-23(31(33,34)35)15-25(16-24)37-30(43)38(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(40)36-17-27(39)29(41)42/h4,6-16,27,39H,1-3,5,17-18H2,(H,36,40)(H,37,43)(H,41,42)/t27-/m1/s1 | PDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50244508
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methoxy...)Show SMILES COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2=CCCCC2)cc(c1)C(F)(F)F |r,t:33| Show InChI InChI=1S/C32H32F3N3O6/c1-44-27-16-24(32(33,34)35)15-25(17-27)37-31(43)38(26-13-11-22(12-14-26)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-28(39)30(41)42/h5,7-17,28,39H,2-4,6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t28-/m1/s1 | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245059
((R)-3-{4-[3-(3-Chlorophenyl)-1-(4-cyclohex-1-enylp...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cccc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:30| Show InChI InChI=1S/C30H30ClN3O5/c31-24-7-4-8-25(17-24)33-30(39)34(26-15-13-22(14-16-26)21-5-2-1-3-6-21)19-20-9-11-23(12-10-20)28(36)32-18-27(35)29(37)38/h4-5,7-17,27,35H,1-3,6,18-19H2,(H,32,36)(H,33,39)(H,37,38)/t27-/m1/s1 | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50244454
((R/S)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dic...)Show SMILES OC(CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |t:31| Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39) | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202041
(CHEMBL375167 | trans-3-{4-[3-(3,5-Bis(trifluoromet...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,wU:4.3,wD:7.10,(30.95,-37.95,;30.96,-39.49,;32.5,-39.49,;29.42,-39.5,;30.95,-41.03,;32.28,-41.81,;32.28,-43.34,;30.94,-44.11,;29.61,-43.35,;29.62,-41.8,;30.95,-45.65,;29.61,-46.42,;28.28,-45.65,;26.94,-46.42,;25.61,-45.65,;25.61,-44.11,;26.94,-43.34,;28.27,-44.1,;24.28,-43.34,;24.28,-41.8,;22.94,-44.11,;21.61,-43.34,;20.27,-44.11,;18.94,-43.34,;18.94,-41.8,;17.61,-44.11,;32.28,-46.42,;32.28,-47.96,;33.61,-45.64,;34.95,-46.41,;36.27,-45.64,;37.6,-46.4,;37.61,-47.95,;36.28,-48.72,;34.94,-47.95,;36.28,-50.26,;36.27,-51.79,;37.82,-50.26,;34.74,-50.26,;38.93,-45.62,;40.26,-44.84,;39.71,-46.95,;38.15,-44.3,)| Show InChI InChI=1S/C30H35F6N3O4/c1-28(2,3)20-8-10-24(11-9-20)39(17-18-4-6-19(7-5-18)26(42)37-13-12-25(40)41)27(43)38-23-15-21(29(31,32)33)14-22(16-23)30(34,35)36/h4-7,14-16,20,24H,8-13,17H2,1-3H3,(H,37,42)(H,38,43)(H,40,41)/t20-,24- | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245062
((R)-3-{4-[3-(3-tert-Butylphenyl)-1-(4-cyclohexylph...)Show SMILES CC(C)(C)c1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)c1 |r| Show InChI InChI=1S/C34H41N3O5/c1-34(2,3)27-10-7-11-28(20-27)36-33(42)37(29-18-16-25(17-19-29)24-8-5-4-6-9-24)22-23-12-14-26(15-13-23)31(39)35-21-30(38)32(40)41/h7,10-20,24,30,38H,4-6,8-9,21-22H2,1-3H3,(H,35,39)(H,36,42)(H,40,41)/t30-/m1/s1 | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50171817
(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)Show SMILES CC(C)(C)C1CCC(CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |(6.78,6.58,;6.79,5.04,;8.33,5.04,;5.25,5.03,;6.79,3.5,;8.12,2.72,;8.12,1.19,;6.78,.42,;5.45,1.18,;5.45,2.73,;6.78,-1.12,;5.45,-1.89,;4.11,-1.12,;2.78,-1.9,;1.44,-1.12,;1.44,.42,;2.77,1.19,;4.11,.43,;.11,1.19,;.11,2.73,;-1.22,.42,;-2.56,1.19,;-3.89,.42,;-5.22,1.19,;-5.23,2.73,;-6.56,.42,;8.12,-1.89,;8.12,-3.43,;9.45,-1.12,;10.78,-1.88,;10.78,-3.42,;12.11,-4.19,;13.44,-3.42,;14.78,-4.19,;14.79,-5.73,;14.77,-7.26,;16.33,-5.73,;13.25,-5.72,;13.44,-1.87,;12.1,-1.11,)| Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37) | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50171817
(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)Show SMILES CC(C)(C)C1CCC(CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |(6.78,6.58,;6.79,5.04,;8.33,5.04,;5.25,5.03,;6.79,3.5,;8.12,2.72,;8.12,1.19,;6.78,.42,;5.45,1.18,;5.45,2.73,;6.78,-1.12,;5.45,-1.89,;4.11,-1.12,;2.78,-1.9,;1.44,-1.12,;1.44,.42,;2.77,1.19,;4.11,.43,;.11,1.19,;.11,2.73,;-1.22,.42,;-2.56,1.19,;-3.89,.42,;-5.22,1.19,;-5.23,2.73,;-6.56,.42,;8.12,-1.89,;8.12,-3.43,;9.45,-1.12,;10.78,-1.88,;10.78,-3.42,;12.11,-4.19,;13.44,-3.42,;14.78,-4.19,;14.79,-5.73,;14.77,-7.26,;16.33,-5.73,;13.25,-5.72,;13.44,-1.87,;12.1,-1.11,)| Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37) | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to GlucR in rat liver membrane |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50244505
((R)-trans-3-{4-[1-(4-tert-Butylcyclohexyl)-3-(3,5-...)Show SMILES Cc1cc(C)cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)c1 |r,wU:30.34,22.23,wD:27.27,(41.34,-18.77,;40.01,-19.54,;40.02,-21.09,;38.69,-21.86,;38.69,-23.4,;37.35,-21.1,;37.36,-19.55,;36.02,-18.79,;34.69,-19.56,;34.69,-21.1,;33.36,-18.79,;32.03,-19.56,;30.69,-18.79,;29.35,-19.57,;28.02,-18.8,;28.02,-17.25,;29.35,-16.48,;30.68,-17.24,;26.69,-16.48,;26.69,-14.94,;25.35,-17.25,;24.02,-16.48,;22.69,-17.25,;22.69,-18.79,;21.35,-16.48,;21.35,-14.94,;20.02,-17.25,;33.36,-17.25,;34.69,-16.48,;34.7,-14.95,;33.36,-14.18,;32.03,-14.95,;32.02,-16.49,;33.37,-12.64,;33.36,-11.09,;34.91,-12.63,;31.83,-12.64,;38.68,-18.78,)| Show InChI InChI=1S/C30H41N3O5/c1-19-14-20(2)16-24(15-19)32-29(38)33(25-12-10-23(11-13-25)30(3,4)5)18-21-6-8-22(9-7-21)27(35)31-17-26(34)28(36)37/h6-9,14-16,23,25-26,34H,10-13,17-18H2,1-5H3,(H,31,35)(H,32,38)(H,36,37)/t23-,25-,26-/m1/s1 | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202031
(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1 |t:33| Show InChI InChI=1S/C30H29Cl2N3O4/c31-24-16-25(32)18-26(17-24)34-30(39)35(27-12-10-22(11-13-27)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(38)33-15-14-28(36)37/h4,6-13,16-18H,1-3,5,14-15,19H2,(H,33,38)(H,34,39)(H,36,37) | PDB
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Inhibition of human cloned glucagon receptor expressed in BHK cells |
J Med Chem 50: 113-28 (2007)
Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50171817
(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)Show SMILES CC(C)(C)C1CCC(CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |(6.78,6.58,;6.79,5.04,;8.33,5.04,;5.25,5.03,;6.79,3.5,;8.12,2.72,;8.12,1.19,;6.78,.42,;5.45,1.18,;5.45,2.73,;6.78,-1.12,;5.45,-1.89,;4.11,-1.12,;2.78,-1.9,;1.44,-1.12,;1.44,.42,;2.77,1.19,;4.11,.43,;.11,1.19,;.11,2.73,;-1.22,.42,;-2.56,1.19,;-3.89,.42,;-5.22,1.19,;-5.23,2.73,;-6.56,.42,;8.12,-1.89,;8.12,-3.43,;9.45,-1.12,;10.78,-1.88,;10.78,-3.42,;12.11,-4.19,;13.44,-3.42,;14.78,-4.19,;14.79,-5.73,;14.77,-7.26,;16.33,-5.73,;13.25,-5.72,;13.44,-1.87,;12.1,-1.11,)| Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37) | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50202222
(CHEMBL398714 | N-tert-butyl-6,7-dichloro-3-(methyl...)Show InChI InChI=1S/C13H15Cl2N3O2S/c1-13(2,3)18-11-12(21(4,19)20)17-10-6-8(15)7(14)5-9(10)16-11/h5-6H,1-4H3,(H,16,18) | PDB
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Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Effect on augmentation of [125]GLP1 binding to human GLP1 |
Bioorg Med Chem Lett 17: 5472-8 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.086
BindingDB Entry DOI: 10.7270/Q2GB23SQ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM29124
(aminothiazole, 21)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(cc2)C(F)(F)F)c2ccc(SC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C28H21F6N3O3S2/c29-27(30,31)20-7-5-18(6-8-20)23-16-41-26(36-23)37(21-9-11-22(12-10-21)42-28(32,33)34)15-17-1-3-19(4-2-17)25(40)35-14-13-24(38)39/h1-12,16H,13-15H2,(H,35,40)(H,38,39) | PDB
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| n/a | n/a | 34 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202047
(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-isopropylph...)Show SMILES CC(C)c1ccc(NC(=O)N(Cc2ccc(cc2)C(=O)NCCC(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)cc1 |r,wU:26.26,wD:29.33,(-2.98,-45.99,;-1.67,-46.79,;-1.71,-48.33,;-.32,-46.06,;-.27,-44.52,;1.08,-43.79,;2.39,-44.6,;3.74,-43.87,;3.79,-42.33,;5.14,-41.6,;2.48,-41.52,;1.12,-42.25,;-.19,-41.45,;-1.55,-42.18,;-2.86,-41.37,;-2.81,-39.82,;-1.45,-39.11,;-.14,-39.91,;-4.12,-39.01,;-4.07,-37.47,;-5.48,-39.74,;-6.79,-38.93,;-8.14,-39.66,;-9.45,-38.85,;-9.41,-37.32,;-10.81,-39.59,;2.52,-39.98,;1.21,-39.18,;1.26,-37.64,;2.62,-36.91,;3.93,-37.72,;3.88,-39.25,;2.67,-35.37,;4.21,-35.39,;1.13,-35.35,;2.72,-33.83,;2.35,-46.13,;1,-46.87,)| Show InChI InChI=1S/C31H43N3O4/c1-21(2)23-10-14-26(15-11-23)33-30(38)34(27-16-12-25(13-17-27)31(3,4)5)20-22-6-8-24(9-7-22)29(37)32-19-18-28(35)36/h6-11,14-15,21,25,27H,12-13,16-20H2,1-5H3,(H,32,37)(H,33,38)(H,35,36)/t25-,27- | PDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Inhibition of human cloned glucagon receptor expressed in BHK cells |
J Med Chem 50: 113-28 (2007)
Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM29106
(aminothiazole, 3)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(OC(F)(F)F)cc2)c2ccc(cc2)C2=CCCCC2)cc1 |t:39| Show InChI InChI=1S/C33H30F3N3O4S/c34-33(35,36)43-28-16-12-25(13-17-28)29-21-44-32(38-29)39(27-14-10-24(11-15-27)23-4-2-1-3-5-23)20-22-6-8-26(9-7-22)31(42)37-19-18-30(40)41/h4,6-17,21H,1-3,5,18-20H2,(H,37,42)(H,40,41) | PDB
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Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50202031
(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1 |t:33| Show InChI InChI=1S/C30H29Cl2N3O4/c31-24-16-25(32)18-26(17-24)34-30(39)35(27-12-10-22(11-13-27)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(38)33-15-14-28(36)37/h4,6-13,16-18H,1-3,5,14-15,19H2,(H,33,38)(H,34,39)(H,36,37) | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to GlucR in rat liver membrane |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202060
(3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluoromethoxy...)Show SMILES CC(C)(C)c1ccc(cc1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C29H30F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-15H,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37) | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50202060
(3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluoromethoxy...)Show SMILES CC(C)(C)c1ccc(cc1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C29H30F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-15H,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37) | PDB
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Rattus norvegicus) | BDBM50171817
(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)Show SMILES CC(C)(C)C1CCC(CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |(6.78,6.58,;6.79,5.04,;8.33,5.04,;5.25,5.03,;6.79,3.5,;8.12,2.72,;8.12,1.19,;6.78,.42,;5.45,1.18,;5.45,2.73,;6.78,-1.12,;5.45,-1.89,;4.11,-1.12,;2.78,-1.9,;1.44,-1.12,;1.44,.42,;2.77,1.19,;4.11,.43,;.11,1.19,;.11,2.73,;-1.22,.42,;-2.56,1.19,;-3.89,.42,;-5.22,1.19,;-5.23,2.73,;-6.56,.42,;8.12,-1.89,;8.12,-3.43,;9.45,-1.12,;10.78,-1.88,;10.78,-3.42,;12.11,-4.19,;13.44,-3.42,;14.78,-4.19,;14.79,-5.73,;14.77,-7.26,;16.33,-5.73,;13.25,-5.72,;13.44,-1.87,;12.1,-1.11,)| Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37) | PDB
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to GIPR in rat liver membrane |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50244455
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichl...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:31| Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1 | PDB
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to GlucR in rat liver membrane |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202056
(CHEMBL219244 | cis-3-{4-[1-(4-tert-butylcyclohexyl...)Show SMILES CC(C)(C)[C@@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r,wD:4.3,7.10,(28.28,-6.28,;26.74,-6.26,;25.21,-6.25,;26.79,-4.72,;26.7,-7.8,;28,-8.62,;27.96,-10.15,;26.59,-10.88,;25.29,-10.08,;25.34,-8.53,;26.55,-12.42,;25.19,-13.15,;23.88,-12.34,;22.52,-13.07,;21.21,-12.26,;21.26,-10.72,;22.62,-10,;23.94,-10.8,;19.95,-9.91,;20,-8.37,;18.6,-10.64,;17.29,-9.83,;15.93,-10.56,;14.62,-9.75,;14.67,-8.21,;13.27,-10.48,;27.86,-13.23,;29.22,-12.49,;27.82,-14.77,;26.46,-15.5,;25.16,-14.68,;23.8,-15.41,;23.76,-16.96,;22.4,-17.69,;22.36,-19.23,;20.82,-19.2,;23.9,-19.26,;22.35,-20.77,;25.08,-17.76,;26.43,-17.03,)| Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)/t21-,23+ | PDB
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Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Inhibition of human cloned glucagon receptor expressed in BHK cells |
J Med Chem 50: 113-28 (2007)
Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM29107
(aminothiazole, 4)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(cc2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1 |t:38| Show InChI InChI=1S/C33H30F3N3O3S/c34-33(35,36)27-14-10-25(11-15-27)29-21-43-32(38-29)39(28-16-12-24(13-17-28)23-4-2-1-3-5-23)20-22-6-8-26(9-7-22)31(42)37-19-18-30(40)41/h4,6-17,21H,1-3,5,18-20H2,(H,37,42)(H,40,41) | PDB
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Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM29109
(aminothiazole, 6)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(OC(F)(F)F)cc2)c2ccc-3c(Cc4ccccc-34)c2)cc1 Show InChI InChI=1S/C34H26F3N3O4S/c35-34(36,37)44-27-12-9-22(10-13-27)30-20-45-33(39-30)40(19-21-5-7-23(8-6-21)32(43)38-16-15-31(41)42)26-11-14-29-25(18-26)17-24-3-1-2-4-28(24)29/h1-14,18,20H,15-17,19H2,(H,38,43)(H,41,42) | PDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50244456
((S)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichl...)Show SMILES O[C@@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:31| Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m0/s1 | PDB
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| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50245056
((R/S)-3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluorom...)Show SMILES CC(C)(C)c1ccc(cc1)N(Cc1ccc(cc1)C(=O)NCC(O)C(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C29H30F3N3O6/c1-28(2,3)20-8-12-22(13-9-20)35(27(40)34-21-10-14-23(15-11-21)41-29(30,31)32)17-18-4-6-19(7-5-18)25(37)33-16-24(36)26(38)39/h4-15,24,36H,16-17H2,1-3H3,(H,33,37)(H,34,40)(H,38,39) | PDB
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| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GluR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50144009
(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |wU:4.3,wD:7.10,(10.18,2.9,;9.39,1.56,;8.05,2.34,;8.62,.21,;10.74,.78,;12.08,1.53,;13.41,.77,;13.41,-.77,;12.07,-1.54,;10.74,-.77,;14.74,-1.54,;14.74,-3.07,;13.39,-3.86,;12.07,-3.1,;10.74,-3.86,;10.74,-5.4,;12.07,-6.17,;13.41,-5.4,;9.41,-6.19,;9.43,-7.72,;8.06,-5.42,;6.74,-6.2,;5.4,-5.44,;4.07,-6.23,;2.73,-5.47,;4.07,-7.77,;16.06,-.77,;16.06,.77,;17.39,-1.54,;18.71,-.77,;20.04,-1.53,;21.38,-.77,;21.36,.78,;22.71,1.56,;22.7,3.09,;21.17,3.11,;24.23,3.11,;22.71,4.62,;20.04,1.55,;18.71,.77,)| Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)/t21-,23- | PDB
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| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Inhibition of human cloned glucagon receptor expressed in BHK cells |
J Med Chem 50: 113-28 (2007)
Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50144009
(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |wU:4.3,wD:7.10,(10.18,2.9,;9.39,1.56,;8.05,2.34,;8.62,.21,;10.74,.78,;12.08,1.53,;13.41,.77,;13.41,-.77,;12.07,-1.54,;10.74,-.77,;14.74,-1.54,;14.74,-3.07,;13.39,-3.86,;12.07,-3.1,;10.74,-3.86,;10.74,-5.4,;12.07,-6.17,;13.41,-5.4,;9.41,-6.19,;9.43,-7.72,;8.06,-5.42,;6.74,-6.2,;5.4,-5.44,;4.07,-6.23,;2.73,-5.47,;4.07,-7.77,;16.06,-.77,;16.06,.77,;17.39,-1.54,;18.71,-.77,;20.04,-1.53,;21.38,-.77,;21.36,.78,;22.71,1.56,;22.7,3.09,;21.17,3.11,;24.23,3.11,;22.71,4.62,;20.04,1.55,;18.71,.77,)| Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)/t21-,23- | PDB
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| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Inhibition of rat glucagon receptor |
J Med Chem 50: 113-28 (2007)
Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202041
(CHEMBL375167 | trans-3-{4-[3-(3,5-Bis(trifluoromet...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,wU:4.3,wD:7.10,(30.95,-37.95,;30.96,-39.49,;32.5,-39.49,;29.42,-39.5,;30.95,-41.03,;32.28,-41.81,;32.28,-43.34,;30.94,-44.11,;29.61,-43.35,;29.62,-41.8,;30.95,-45.65,;29.61,-46.42,;28.28,-45.65,;26.94,-46.42,;25.61,-45.65,;25.61,-44.11,;26.94,-43.34,;28.27,-44.1,;24.28,-43.34,;24.28,-41.8,;22.94,-44.11,;21.61,-43.34,;20.27,-44.11,;18.94,-43.34,;18.94,-41.8,;17.61,-44.11,;32.28,-46.42,;32.28,-47.96,;33.61,-45.64,;34.95,-46.41,;36.27,-45.64,;37.6,-46.4,;37.61,-47.95,;36.28,-48.72,;34.94,-47.95,;36.28,-50.26,;36.27,-51.79,;37.82,-50.26,;34.74,-50.26,;38.93,-45.62,;40.26,-44.84,;39.71,-46.95,;38.15,-44.3,)| Show InChI InChI=1S/C30H35F6N3O4/c1-28(2,3)20-8-10-24(11-9-20)39(17-18-4-6-19(7-5-18)26(42)37-13-12-25(40)41)27(43)38-23-15-21(29(31,32)33)14-22(16-23)30(34,35)36/h4-7,14-16,20,24H,8-13,17H2,1-3H3,(H,37,42)(H,38,43)(H,40,41)/t20-,24- | PDB
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| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Inhibition of human cloned glucagon receptor expressed in BHK cells |
J Med Chem 50: 113-28 (2007)
Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202051
(CHEMBL373824 | trans-3-(4-((1-(4-tert-butylcyclohe...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1C#N |r,wU:7.10,wD:4.3,(7.81,-36.16,;6.27,-36.14,;4.73,-36.12,;6.32,-34.6,;6.22,-37.68,;4.86,-38.41,;4.81,-39.95,;6.11,-40.75,;7.48,-40.02,;7.52,-38.49,;6.07,-42.29,;4.72,-43.02,;3.4,-42.22,;2.04,-42.95,;.73,-42.14,;.78,-40.59,;2.15,-39.88,;3.46,-40.68,;-.53,-39.78,;-.48,-38.24,;-1.88,-40.51,;-3.19,-39.7,;-4.55,-40.43,;-5.86,-39.62,;-5.81,-38.09,;-7.21,-40.36,;7.38,-43.1,;8.74,-42.37,;7.34,-44.64,;5.98,-45.37,;4.68,-44.56,;3.32,-45.29,;3.28,-46.83,;1.92,-47.56,;1.88,-49.1,;1.87,-50.64,;.34,-49.07,;3.42,-49.13,;4.6,-47.64,;5.95,-46.9,;7.26,-47.7,;8.57,-48.5,)| Show InChI InChI=1S/C30H35F3N4O5/c1-29(2,3)22-8-10-23(11-9-22)37(18-19-4-6-20(7-5-19)27(40)35-15-14-26(38)39)28(41)36-25-13-12-24(16-21(25)17-34)42-30(31,32)33/h4-7,12-13,16,22-23H,8-11,14-15,18H2,1-3H3,(H,35,40)(H,36,41)(H,38,39)/t22-,23- | PDB
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| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Inhibition of human cloned glucagon receptor expressed in BHK cells |
J Med Chem 50: 113-28 (2007)
Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202029
(3-(4-((1-(4-isopropylcyclohexyl)-3-(4-(trifluorome...)Show SMILES CC(C)C1CCC(CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |(25.03,-34.49,;23.7,-35.26,;22.37,-34.49,;23.7,-36.8,;25.03,-37.58,;25.03,-39.11,;23.69,-39.88,;22.36,-39.12,;22.36,-37.57,;23.69,-41.42,;22.36,-42.19,;21.02,-41.42,;19.69,-42.19,;18.35,-41.42,;18.35,-39.88,;19.68,-39.11,;21.02,-39.87,;17.02,-39.11,;17.02,-37.57,;15.69,-39.88,;14.35,-39.11,;13.02,-39.88,;11.68,-39.11,;11.69,-37.57,;10.35,-39.88,;25.02,-42.18,;25.03,-43.72,;26.36,-41.41,;27.69,-42.18,;27.69,-43.72,;29.02,-44.49,;30.35,-43.72,;31.69,-44.48,;31.69,-46.02,;31.68,-47.56,;33.23,-46.03,;30.15,-46.02,;30.35,-42.17,;29.01,-41.41,)| Show InChI InChI=1S/C28H34F3N3O5/c1-18(2)20-7-11-23(12-8-20)34(27(38)33-22-9-13-24(14-10-22)39-28(29,30)31)17-19-3-5-21(6-4-19)26(37)32-16-15-25(35)36/h3-6,9-10,13-14,18,20,23H,7-8,11-12,15-17H2,1-2H3,(H,32,37)(H,33,38)(H,35,36) | PDB
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| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Inhibition of human cloned glucagon receptor expressed in BHK cells |
J Med Chem 50: 113-28 (2007)
Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50202039
(3-(4-((1-(4-cyclohexylphenyl)-3-(4-(trifluorometho...)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2ccc(OC(F)(F)F)cc2)c2ccc(cc2)C2CCCCC2)cc1 Show InChI InChI=1S/C31H32F3N3O5/c32-31(33,34)42-27-16-12-25(13-17-27)36-30(41)37(26-14-10-23(11-15-26)22-4-2-1-3-5-22)20-21-6-8-24(9-7-21)29(40)35-19-18-28(38)39/h6-17,22H,1-5,18-20H2,(H,35,40)(H,36,41)(H,38,39) | PDB
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| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Inhibition of human cloned glucagon receptor expressed in BHK cells |
J Med Chem 50: 113-28 (2007)
Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50202031
(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1 |t:33| Show InChI InChI=1S/C30H29Cl2N3O4/c31-24-16-25(32)18-26(17-24)34-30(39)35(27-12-10-22(11-13-27)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(38)33-15-14-28(36)37/h4,6-13,16-18H,1-3,5,14-15,19H2,(H,33,38)(H,34,39)(H,36,37) | PDB
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| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245062
((R)-3-{4-[3-(3-tert-Butylphenyl)-1-(4-cyclohexylph...)Show SMILES CC(C)(C)c1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)c1 |r| Show InChI InChI=1S/C34H41N3O5/c1-34(2,3)27-10-7-11-28(20-27)36-33(42)37(29-18-16-25(17-19-29)24-8-5-4-6-9-24)22-23-12-14-26(15-13-23)31(39)35-21-30(38)32(40)41/h7,10-20,24,30,38H,4-6,8-9,21-22H2,1-3H3,(H,35,39)(H,36,42)(H,40,41)/t30-/m1/s1 | PDB
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| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM29119
(aminothiazole, 16)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(cc2)C(F)(F)F)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C27H21ClF3N3O3S/c28-21-9-11-22(12-10-21)34(15-17-1-3-19(4-2-17)25(37)32-14-13-24(35)36)26-33-23(16-38-26)18-5-7-20(8-6-18)27(29,30)31/h1-12,16H,13-15H2,(H,32,37)(H,35,36) | PDB
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| n/a | n/a | 76 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM29114
(aminothiazole, 11)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(cc2)C(F)(F)F)c2ccc3CCCCc3c2)cc1 Show InChI InChI=1S/C31H28F3N3O3S/c32-31(33,34)25-12-9-22(10-13-25)27-19-41-30(36-27)37(26-14-11-21-3-1-2-4-24(21)17-26)18-20-5-7-23(8-6-20)29(40)35-16-15-28(38)39/h5-14,17,19H,1-4,15-16,18H2,(H,35,40)(H,38,39) | PDB
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| PC cid
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| n/a | n/a | 77 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM29128
(aminothiazole, 25)Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)N(Cc1ccc-2c(Cc3ccccc-23)c1)c1nc(cs1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C34H26F3N3O3S/c35-34(36,37)26-10-6-22(7-11-26)30-20-44-33(39-30)40(27-12-8-23(9-13-27)32(43)38-16-15-31(41)42)19-21-5-14-29-25(17-21)18-24-3-1-2-4-28(24)29/h1-14,17,20H,15-16,18-19H2,(H,38,43)(H,41,42) | PDB
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| PC cid
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PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
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