| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50255763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_515526 (CHEMBL1036547) |
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| Ki | 3±n/a nM |
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| Citation |  Jablonowski, JA; Ly, KS; Bogenstaetter, M; Dvorak, CA; Boggs, JD; Dvorak, LK; Lord, B; Miller, KL; Mazur, C; Wilson, SJ; Lovenberg, TW; Carruthers, NI Novel imidazole-based histamine H3 antagonists. Bioorg Med Chem Lett19:903-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50255763 |
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| n/a |
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| Name | BDBM50255763 |
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| Synonyms: | (4-bromophenyl)(2-((1-isopropylpiperidin-4-yl)methoxy)-1-methyl-1H-imidazol-5-yl)methanone | CHEMBL480048 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26BrN3O2 |
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| Mol. Mass. | 420.343 |
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| SMILES | CC(C)N1CCC(COc2ncc(C(=O)c3ccc(Br)cc3)n2C)CC1 |
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| Structure | 
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